Exhibit 99.1 2021 Reference From Itau Unibanco Holding S.A. Itaú Unibanco Holding S.A. REFERENCE FORM Base Date: 12.31.2021 | (in accordance with Attachment 24 to CVM Instruction No. 480 of December 7, 2009 "CVM Instruction No. 480", as amended) | | | --- | --- | | | Itau Unibanco Holding S.A., a corporation enrolled under the National | | | Register of Legal Entities/Ministry of Finance (CNPJ/MF) under No. | | | 60.872.504/0001-23, with its Articles of Incorporation registered with the | | Identification | ...