As filed with the U.S. Securities and Exchange Commission on November 1, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 LIPELLA PHARMACEUTICALS INC. (Exact name of registrant as specified in its charter) Jonathan Kaufman Chief Executive Officer 7800 Susquehanna St. Suite 505 Pittsburgh, PA 15208 (412) 894-1853 (Name, address including zip code, and telephone number, including area code, of ag ...