Registration Statement No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 MAZE THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Table of Contents As filed with the Securities and Exchange Commission on October 17, 2025. Jason Coloma, Ph.D. Chief Executive Officer 171 Oyster Point Blvd., Suite 300 South San Francisco, California ...