Exhibit 2.1 Execution Version AGREEMENT AND PLAN OF MERGER by and among PHREESIA, INC., ACE MERGER SUB, INC., ACCESSONE PARENT HOLDINGS, INC., and FRONTIER FUND IV, L.P., as Representative of the Equityholders August 29, 2025 Certain identified information has been excluded from the exhibit because it is both (i) not material and (ii) is the type that the company treats as private or confidential. Brackets with triple asterisks denote omissions. TABLE OF CONTENTS | ARTICLE | I | THE | MERGER | -2- | 1.01. | ...