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Karyopharm Therapeutics(KPTI) - 2025 Q3 - Quarterly Report

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR (State or other jurisdiction of incorporation or organization) 85 Wells Avenue, 2nd Floor Newton, MA 02459 (Address of principal executive offices) (Zip Code) Delaware 26-3931704 (I.R.S. Employer Identification Number) (617) 658-0600 ☐ TRANSITION REPORT PURS ...