Table of Contents As filed with the Securities and Exchange Commission on October 19, 2026 Registration No. 333-299332 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Pre-Effective Amendment No. 2 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ACTUATE THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 8731 47-3044785 (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code) (I. ...