Engineered hFcRn/B2M–MDCK Transwell system
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Adventures in DMPK: Viva Biotech's One-Stop Pharmacology Platform Cross New Modalities
Prnewswire· 2025-12-29 14:13
Building on this ADME–PK foundation for small molecules and peptides, Viva applies modality-specific strategies to antibody programs, where FcRn biology becomes a central determinant of pharmacokinetic behavior. A central technical highlight was Viva Biotech's engineered hFcRn/B2M–MDCK Transwell system for antibody transcytosis, developed to generate a cell-based readout of FcRn-mediated transport and to enable time- and dose-dependent transcytosis measurements. Positioned as a cost- and time-efficient appr ...