As filed with the Securities and Exchange Commission on January 16, 2026. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SpyGlass Pharma, Inc. (Exact name of registrant as specified in its charter) (State or other jurisdiction of (Primary Standard Industrial Classification Code Number) Delaware 3841 83-3044245 (I.R.S. Employer Identification Number) 27061 Aliso Creek Rd., Suite 100 Aliso Viejo, Ca ...