Athira Pharma Inc. (NASDAQ:ATHA) stock is trading higher on Thursday, with a session volume of 57.29 million compared to the average volume of 30.94 thousand as per data from Benzinga Pro.Athira Pharma on Thursday agreed to acquire the rights for the development and commercialization of lasofoxifene, a clinical asset in a potentially registrational Phase 3 trial.The ongoing Phase 3 ELAINE-3 clinical trial is greater than 50% enrolled, with data expected in mid-2027.Athira has acquired an exclusive global li ...

Athira Pharma, Inc. (ATHA) shares surged 69.53 percent, gaining $2.88 to trade at $7.01 on Thursday, after the clinical-stage biopharmaceutical company announced an agreement to acquire global development and commercialization rights to lasofoxifene, a Phase 3 ready asset for metastatic breast cancer. The stock was trading at $7.01, up sharply from a previous close of $4.14 on the Nasdaq. Shares opened at $7.22 and moved within a day's range of $6.77 to $8.35. Trading volume spiked to about 53.19 million s ...

U.S. stocks traded higher midway through trading, with the Nasdaq Composite gaining more than 200 points on Thursday.The Dow traded up 0.44% to 48,097.08 while the NASDAQ jumped 1.08% to 22,938.56. The S&P 500 also rose, gaining, 0.76% to 6,772.76.Check This Out: Wall Street’s Most Accurate Analysts Give Their Take On 3 Materials Stocks Delivering High-Dividend YieldsLeading and Lagging SectorsConsumer discretionary shares rose by 2% on Thursday.In trading on Thursday, energy stocks fell by 0.5%.Top Headlin ...

U.S. stocks traded higher this morning, with the Dow Jones index gaining around 400 points on Thursday.The Dow traded up 0.84% to 48,289.58 while the NASDAQ jumped 1.53% to 23,040.25. The S&P 500 also rose, gaining, 1.09% to 6,794.36.Check This Out: Wall Street’s Most Accurate Analysts Give Their Take On 3 Materials Stocks Delivering High-Dividend YieldsLeading and Lagging SectorsConsumer discretionary shares rose by 1.6% on Thursday.In trading on Thursday, energy stocks fell by 0.8%.Top HeadlineAccenture ( ...

研发进展 - Lasofoxifene的III期注册研究正在进行中，已超过50%的患者入组[16] - ATH-1105的II期POC研究计划于2026年上半年启动[18] - Lasofoxifene的FDA对齐注册III期试验正在进行中[28] - ELAINE-3试验预计在2027年上半年公布初步结果，超过50%的患者已完成入组[57] - Lasofoxifene的FDA推荐组合比较试验正在进行中，预计将为其注册提供支持[1] 临床试验结果 - Lasofoxifene在重度预处理的mESR1人群中，潜在的最佳中位无进展生存期（PFS）为13个月[27] - Lasofoxifene在mESR1人群中与标准治疗fulvestrant相比，显示出更长的中位无进展生存期（PFS），为24.2周（95% CI: 11.3-32.1），而fulvestrant为16.2周（95% CI: 11.7-24.1）[48] - ELAINE-2试验中，Lasofoxifene与abemaciclib联合治疗的中位PFS为13个月（56周）[50] - Lasofoxifene的客观反应率（ORR）为13%，而fulvestrant的ORR仅为3%[48] - ELAINE-1试验中，Lasofoxifene的临床获益率（CBR）为37%，而fulvestrant为22%[48] 市场前景 - 全球转移性ER+/HER2-市场预计将从2025年的约109亿美元增长至2029年的约159亿美元[23] - Lasofoxifene在2L/3L ESR1突变转移性乳腺癌中的市场潜力超过10亿美元，假设市场渗透率约为10%[81] - 全球乳腺癌市场预计到2027年将达到550亿美元[83] - 公司在ALS领域的临床开发项目具有多十亿美元的市场机会[136] 安全性与耐受性 - Lasofoxifene在临床试验中表现出良好的安全性和耐受性，可能带来生活质量的改善[24] - Lasofoxifene的安全性和耐受性表现良好，3级腹泻发生率为0%，而Imlunestrant + Abema为9%[1] - Lasofoxifene的贫血发生率为28%，而Imlunestrant + Abema为46%[1] 资金与融资 - 公司PIPE融资最高可达2.36亿美元，其中9000万美元的前期融资将支持Lasofoxifene开发项目，资金可持续至2028年[137] 其他信息 - Lasofoxifene的治疗在减少尿生殖道症状方面优于fulvestrant，显示出对女性健康的潜在益处[63] - Lasofoxifene的临床试验结果显示其在耐受性和生活质量方面具有优势，可能推动其成为新的内分泌治疗基础药物[76] - ATH-1105在ALS小鼠模型中，早期治疗与延迟治疗均能减缓疾病进展，延迟治疗开始后观察到血浆NfL水平降低[122] - ATH-1105在体内表现出快速吸收和一致的消除，且在重复给药10天后未出现药物积累[128]

Phase 3 Development Program of Novel Selective Estrogen Receptor Modulator (SERM) Represents Potential Multi-Billion Dollar Opportunity as Treatment Option for Patients with ESR1-Mutations Financing Co-Led by Commodore Capital, Perceptive Advisors and TCGX Supports Development of Lasofoxifene through Phase 3 Clinical Topline Data Readout and Regulatory Milestones Conference Call Today at 8:30 am Eastern Time BOTHELL, Wash., Dec. 18, 2025 (GLOBE NEWSWIRE) -- Athira Pharma, Inc. (NASDAQ: ATHA), a clinical-sta ...