AN9025, an orally bioavailable pan-RAS(ON) inhibitor with potent, broad-spectrum anti-tumor activity Background 0 100 200 300 400 Time(s) Response(nm) 0 0.1 0.2 0.3 Kinetic analysis of RMC-6236 Binding to CypA KD1=12.4 nM 0 100 200 300 400 Time(s) 0 0.1 0.3 0.2 Kinetic analysis of AN9025 Binding to CypA KD1=3.2 nM Response(nm) A B AN9025 forms a tri-complex with high affinity Figure 2. Binding kinetics of AN9025 and RMC-6236 to CypA. His-tagged CypA was immo- bilized on an NTA sensor and then incubated with ...