Blood Version 1 Version 2 CRC Sensitivity 84% 91% Study Results • Samples were run on both V1 and V2 tests ) GUARDANT Source: Guardant internal data Adding Shield to standard of care increases compliance meaningfully Randomized prospective study with Kaiser Permanente Center for Health Research ACG ** 2023 9 Shield V2 demonstrated improved clinical sensitivity relative to Shield V1 CRC Sensitivity N = 45 Specificity N = 1,458 84% (38/45) 91% Shield V1 – PMA device Shield V2 91% (41/45) 91% CRC Sensitivity N ...