FORCE Targets Toxic Nuclear DMPK RNA RNaseH1 Approximately 10 Normal DMPK mRNA Normal DMPK mRNA is able to leave the nucleus Toxic DMPK mRNA is unable to leave the nucleus Approximately 10 Toxic DMPK mRNA Toxic DMPK RNA sequesters MBNL and forms foci Nucleus Cell Membrane ASO ASO binds DMPK RNA RNaseH1 cleaves DMPK RNA MBNL is released to restore splicing Cytoplasm in the nucleus Endosome TfR1 FORCE 16 Robust Preclinical Data Supporting the Potential of DYNE-101 to Drive Disease Modification in the Clinic | ...