Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36193 Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisdicti ...

Trevena, Inc. (OTC:TRVN) Q4 2021 Earnings Conference Call March 31, 2022 8:00 AM ET Company Participants Barry Shin - Senior Vice President and Chief Financial Officer Carrie Bourdow - President and Chief Executive Officer Patricia Drake - Senior Vice President and Chief Commercial Officer Mark Demitrack - Senior Vice President and Chief Medical Officer Conference Call Participants Brandon Folkes - Cantor Fitzgerald Jason Butler - JMP Securities Douglas Tsao - H.C. Wainwright & Co. Jeff Jones - Oppenheimer ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36193 Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 26-1469215 (State or Other Juri ...

Trevena, Inc. (OTC:TRVN) Q3 2021 Earnings Conference Call November 15, 2021 8:00 AM ET Company Participants Barry Shin - Senior Vice President and Chief Financial Officer Carrie Bourdow - President and Chief Executive Officer Patty Drake - Chief Commercial Officer Bob Yoder - Chief Business Officer and Head, Commercial Operations Mark Demitrack - Chief Medical Officer Paul Ryder - Professor, University of South Alabama Conference Call Participants Jason Butler - JMP Securities Jeff Jones - Oppenheimer Chris ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36193 Trevena, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware (State or Other Jurisd ...

INNOVATING FOR PATIENTS Nasdaq TRVN I August 2021 Forward-Looking Statements To the extent that statements contained in this presentation are not descriptions of historical facts regarding Trevena, Inc. (the "Company" or "we"), they are forward-looking statements reflecting management's current beliefs and expectations. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry's actual results, levels of activity, performance, or a ...

Trevena, Inc (OTC:TRVN) Q2 2021 Earnings Conference Call August 12, 2021 8:00 AM ET Company Participants Barry Shin – Chief Financial Officer Carrie Bourdow – President and Chief Executive Officer Bob Yoder – Chief Commercial Officer Mark Demitrack – Chief Medical Officer Conference Call Participants Brandon Folkes – Cantor Fitzgerald Jason Butler – JBS Securities Douglas Tsao – H.C. Wainwright Operator Thank you for standing by, and welcome to the Trevena Incorporated Second Quarter 2021 Financial Results ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Delaware (State or Other Jurisdiction of Incorporation or Organization) 26-1469215 (I.R.S. Employer Identification No.) 955 Chesterbrook Boulevard, Suite 110 Chesterbrook, PA (Address of Principal Executive Offices) 19087 (Zip Code) For the quarterly period ended June 30, 2021 Or ☐ TRANSITION REPORT PURSUANT T ...

Trevena, Inc. (OTC:TRVN) Q1 2021 Earnings Conference Call May 6, 2021 8:00 AM ET Company Participants Barry Shin - SVP & CFO Carrie Bourdow - President, CEO & Director Robert Yoder - SVP & Chief Commercial Officer Mark Demitrack - SVP & Chief Medical Officer Conference Call Participants Jason Butler - JMP Securities Brandon Folkes - Cantor Fitzgerald & Co. Dana Flanders - Guggenheim Securities Jeffrey Jones - Oppenheimer Douglas Tsao - H.C. Wainwright & Co. Operator Good day, and thank you for standing by, ...

INNOVATING FOR PATIENTS Nasdaq TRVN I May 2021 Forward-Looking Statements To the extent that statements contained in this presentation are not descriptions of historical facts regarding Trevena, Inc. (the "Company" or "we"), they are forward-looking statements reflecting management's current beliefs and expectations. Forward-looking statements are subject to known and unknown risks, uncertainties, and other factors that may cause our or our industry's actual results, levels of activity, performance, or achi ...