Table of Contents As filed with the Securities and Exchange Commission on December 1, 2023 Registration No. 333-________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 APTOSE BIOSCIENCES INC. (Exact Name of Registrant As Specified In Its Charter) (State or other jurisdiction of incorporation or organization) Canada 2836 98-1136802 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification ...