As filed with the Securities and Exchange Commission on August 22, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 Table of Contents REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 MEDICINOVA, INC. (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) Delaware 2834 33-0927979 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification Number) 4275 E ...