(State or Other Jurisdiction of Incorporation or Organization) (Primary Standard Industrial Classification Code Number) As filed with the Securities and Exchange Commission on October 23, 2023. Registration Statement No. 333-274562 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to Form S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Avenue Therapeutics, Inc. (Exact name of registrant as specified in its charter) If this Form is filed to register additiona ...