Table of Contents Index to Financial Statements As filed with the Securities and Exchange Commission on December 14, 2023. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FRACTYL HEALTH, INC. Harith Rajagopalan, M.D., Ph.D. Chief Executive Officer Fractyl Health, Inc. 17 Hartwell Avenue Lexington, MA 02421 (781) 902-8800 (Name, address, including zip code, and telephone number, including area code, ...