As filed with the Securities and Exchange Commission on October 14, 2025 Registration No. 333-289285 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to Form F-3 on Form F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Psyence Biomedical Ltd. (Exact Name of Registrant as Specified in Its Charter) (State or Other Jurisdiction of Incorporation or Organization) Ontario, Canada 2834 Not Applicable (Primary Standard Industrial Classification Code Number) (I.R.S. ...