Table of Contents As filed with the Securities and Exchange Commission on June 7, 2024 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 (Address of principal executive offices) Not Applicable (Zip Code) +353 1 6694820 ITERUM THERAPEUTICS PLC (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classificatio ...