Table of Contents As filed with the Securities and Exchange Commission on July 17, 2024 Registration No. 333-280045 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ITERUM THERAPEUTICS PLC (Exact name of registrant as specified in its charter) (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) (Address of principal executive offices) ...