Exhibit 99.1 September 30, 2021 TO THE SHAREHOLDERS OF PYXIS TANKERS INC. Enclosed is a Notice of the 2021 Annual Meeting of Shareholders (the "Meeting") of Pyxis Tankers Inc. (the "Company"), which will be held at the Company's offices at 59, K. Karamanli Street, Maroussi 15125, Greece on Thursday, November 11, 2021 at 4:30 p.m., Greek time, the Company's Proxy Statement and certain other related materials. These materials, together with the Company's annual report on Form 20-F, which contains the Company' ...