FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ________ to _________ Commission file number 001-41210 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 HILLSTREAM BIOPHARMA, INC. (Exact name of registrant as specified in charter) | Delaware | 84-2642541 | | --- | --- | | (S ...