Orchestra BioMed Holdings, Inc. Shares have lost about 48.4% since the beginning of the year versus the S&P 500's gain of 9.5%. What's Next for Orchestra BioMed Holdings, Inc. Orchestra BioMed Holdings, Inc. (OBIO) came out with a quarterly loss of $0.38 per share versus the Zacks Consensus Estimate of a loss of $0.40. This compares to loss of $0.40 per share a year ago. These figures are adjusted for non-recurring items. This quarterly report represents an earnings surprise of 5%. A quarter ago, it was exp ...