ALPS Medical Breakthroughs ETF (SBIO US) – Portfolio Construction MethodologyThe underlying S-Network Medical Breakthroughs Index provides exposure to US-listed biotechnology developers in the small- and mid-cap bracket with late-stage drug pipelines. The universe is companies listed on a US exchange and principally engaged in biotechnology. Eligible constituents must have market cap between 200 million and 5 billion USD, sustain 90-day ADTV above 1 million USD, have at least one drug in Phase II or Phase I ...