As filed with the Securities and Exchange Commission on October 21, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Prophase Labs, Inc. Ted Karkus Chief Executive Officer ProPhase Labs, Inc. 626 RXR Plaza, 6th Floor Uniondale, NY 11556 (516) 989-0763 (Exact name of registrant as specified in its charter) (State or Other Jurisdiction of (Primary Standard Industrial (I.R.S. Employer Incorporation ...