• David Connolly, Executive Director of Investor Relations and Corporate Communications • David Meeker, MD, Chair, President and Chief Executive Officer • Jennifer Lee, Executive Vice President, Head of North America • Yann Mazabraud, Executive Vice President, Head of International • Hunter Smith, Chief Financial Officer Rhythm Pharmaceuticals Third Quarter 2025 Financial Results and Business Update November 4, 2025 ® © Rhythm® Pharmaceuticals, Inc. All rights reserved. On Today's Call ® 2 Forward-looking S ...