Forward-looking statements Topline results Phase 3 RISE UP in sickle cell disease November 19, 2025 This presentation and various remarks we make during this presentation contain forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding the potential benefits of mitapivat; Agios' plans for future meetings with, or submissions to, regulators, including the FDA; Agios' plans for the development of mitapivat, t ...