Northern Trust Corporation .Fourth Quarter 2021 Quarterly Earnings Review . January 20, 2022 northerntrust.com | © 2022 Northern northerntrust.com | © 2022 NorthernTrust 1 EXECUTIVE SUMMARY 4Q21 End of Period Month Lag1 Quarter Lag2 YoY Seq YoY Seq YoY Seq Net income of $406.4 million, diluted earnings per common share of $1.91 Return on average common equity of 14.5% The current quarter included: Key Macroeconomic Factors 1 Month Lag YoY represents the average month-ends of Sept. 2021 – Nov. 2021 vs. Sept. ...