Findings highlight PL9654 and PL9655's potential to treat diabetic retinopathy through inflammation resolution, vascular stabilization, and neuroprotection PL9654 and PL9655 down-regulate inflammatory pathways, suppress angiogenesis, and preserve retinal structure and function Topical and systemic administration options enable potential for earlier intervention than current therapies Results support the continued development of PL9654 and PL9655 for the treatment of diabetic retinopathy (DR)CRANBURY, N.J., ...

Funding Supports Advancement of Obesity Program and Strategic Business Development Initiatives Advancement of novel next-generation MC4R long-acting peptides and oral small molecules IND applications planned for Q4 2025; clinical data expected H1 2026 Phase 1 SAD/MAD studies to include patients with hypothalamic obesity Ocular asset collaborations expected in Q2 and Q3 2025CRANBURY, N.J., May 7, 2025 /PRNewswire/ -- Palatin Technologies, Inc. (the "Company" or "Palatin") (NYSE American: PTN), a biopharmac ...

Topical melanocortin therapy shows promise for treating glaucoma PL9588 lowers intraocular pressure (IOP) by increasing aqueous outflow Demonstrates neuroprotection independent of IOP reduction Supports continued development of PL9588 as a novel, dual-action glaucoma therapyCRANBURY, N.J., May 5, 2025 /PRNewswire/ -- Palatin Technologies, Inc. (NYSE American: PTN), a biopharmaceutical company advancing innovative treatments targeting the melanocortin receptor system, today announced new preclinical data fo ...

Updated Phase 3 analyses position PL9643 as a potential first-in-class therapy achieving full symptom resolution in dry eye disease. Responder analyses demonstrated statistically significant symptom clearing (resolution) across multiple endpoints in patients treated with PL9643, compared to placebo. Six of 13 symptom endpoints showed a significantly higher percentage of patients in the PL9643 group achieving complete symptom resolution compared to placebo (p<0.05). This level of symptom clearing has not b ...

公司动态 - Palatin Technologies宣布其Phase 2b BREAKOUT研究数据将在美国肾脏基金会春季会议上展示 研究评估了黑色素皮质素激动剂对II型糖尿病肾病患者的效果 [1] - 公司CEO表示这是黑色素皮质素平台在代谢、眼部和炎症疾病领域的第三个重要临床里程碑 此前已在肥胖和溃疡性结肠炎研究中取得积极数据 并推进了干眼症Phase 3项目 [2] - BREAKOUT研究在美国多个中心招募了16名II型糖尿病肾病患者 其中8名完成了6个月的治疗方案 患者在RAAS抑制疗法基础上接受每日两次皮下注射bremelanotide [2] 临床研究结果 - 6个月开放标签研究显示 低剂量黑色素皮质素激动剂治疗带来临床意义的肾脏功能改善 [3] - 71%患者尿蛋白/肌酐比值(UP/Cr)降低超过30% 这是肾脏损伤的关键指标 [6][7] - 71%患者肾小球滤过率(eGFR)改善或稳定 表明肾功能得到保护 [6][7] - 37.5%患者尿血管内皮生长因子(VEGF)水平升高 提示肾脏血管支持改善 [6][7] - 36%患者尿synaptopodin损失减少 显示肾脏细胞和结构更健康 [6][7] 技术平台 - 黑色素皮质素受体系统通过调节炎症、免疫反应、代谢等功能产生药理作用 有5种受体亚型(MC1R-MC5R) [4] - 该受体在眼部、肠道和肾脏等组织表达 为直接激活天然通路解决疾病炎症提供可能 [5] - MC1r激活可能通过蛋白激酶A途径稳定糖尿病肾病的足细胞功能和存活 [10] 疾病背景 - 糖尿病肾病是美国等发达国家终末期肾病最常见原因 约3000万美国患者因高血压合并II型糖尿病导致慢性肾病 [6][8] - 尽管RAAS阻断广泛使用 仍有约1/3II型糖尿病肾病患者会进展至终末期肾病 [8] - 肾小球足细胞损伤是糖尿病肾病发病核心 临床治疗应着眼于维持足细胞活性 [9] 公司战略 - Palatin专注于开发调节黑色素皮质素受体系统的首创药物 针对未满足医疗需求的疾病领域 [11] - 公司策略是开发产品后建立营销合作以最大化商业潜力 [11]