As filed with the Securities and Exchange Commission on August 8, 2025 Registration No. 333- (State or Other Jurisdiction of Incorporation or Organization) Delaware 3841 85-3681132 (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identification No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SeaStar Medical Holding Corporation (Exact Name of Registrant as Specified in Its Charter) 3513 Brigh ...

REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on September 8, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Code Number) 3513 Brighton Blvd, Suite 410 Denver, CO 80216 (844) 427-8100 (Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant's Principal Executive Offices) Eric Schlorff Chief Executive Officer 3513 Brighton Blvd. Suite 410 Denver, CO 80216 UNDER THE S ...

Table of Contents REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on July 20, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SeaStar Medical Holding Corporation (Exact Name of Registrant as Specified in Its Charter) (State or Other Jurisdiction of Incorporation or Organization) Delaware 6770 85-3681132 (Primary Standard Industrial Classification Code Number) (I.R.S ...

Table of Contents REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on April 24, 2023 Registration No.333-271215 UNITED STATES SECURITIES AND EXCHANGE COMMISSION 3513 Brighton Blvd, Suite 410 Denver, CO 80216 (844) 427-8100 (Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant's Principal Executive Offices) Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SeaStar Medical Holding Corporation ( ...

Table of Contents REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on April 11, 2023 Registration No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SeaStar Medical Holding Corporation (Exact Name of Registrant as Specified in Its Charter) (State or Other Jurisdiction of Incorporation or Organization) Delaware 6770 85-3681132 (Primary Standard Industrial Classification Code Number) (I.R.S. Em ...

Table of Contents REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on January 20, 2023 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SeaStar Medical Holding Corporation (Exact Name of Registrant as Specified in Its Charter) (State or Other Jurisdiction of Incorporation or Organization) Delaware 6770 85-3681132 (Primary Standard Industrial Classification Code Number) (I. ...

Table of Contents Index to Financial Statements REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on January 4, 2023 Registration No. 333-268503 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SeaStar Medical Holding Corporation (Exact Name of Registrant as Specified in Its Charter) (State or Other Jurisdiction of Incorporation or Organization) Delaware 6770 85-3681132 (Prima ...