FOURTH QUARTER AND FULL YEAR 2022 FINANCIAL RESULTS ©2023 Vertex Pharmaceuticals Incorporated VERTEX FEBRUARY 7, 2023 AGENDA Introduction Susie Lisa, CFA, Senior Vice President, Investor Relations CEO Perspective and Pipeline Update Reshma Kewalramani, M.D., Chief Executive Officer and President Commercial Update Stuart Arbuckle, Executive Vice President and Chief Operating Officer Financial Results Charlie Wagner, Executive Vice President and Chief Financial Officer ©2023 Vertex Pharmaceuticals Incorporate ...