业绩总结 - 公司2025年收入指导为9亿至9.5亿美元[13] - 截至2025年3月31日，公司现金为5.708亿美元[13] 用户数据 - 在CATALYST试验中，1,057名患者中23.8%被发现患有高皮质醇症[21] - GRACE试验中，63%的高血压患者达到了研究的反应标准，收缩压平均改善12.6 mm Hg，舒张压改善8.3 mm Hg（p<0.0001）[29] - GRACE试验中，50%的高血糖患者达到了研究的反应标准，HbA1c平均改善0.7%（p<0.0001）[33] - 381名患者参与ROSELLA试验，主要终点达成，p值为0.008[62] - 116名患者参与relacorilant的长期延续研究，治疗耐受性良好[47] 新产品和新技术研发 - relacorilant的NDA已被接受，PDUFA目标日期为2025年12月30日[24] - GRADIENT试验计划招募137名因肾上腺腺瘤引起的高皮质醇症患者[40] - 在Phase 1b试验中，miricorilant治疗组肝脏脂肪减少约30%[81] - Dazucorilant在ALS患者中，300 mg剂量组的生存率显著改善，HR为0.16，p值为0.0009[66] 市场扩张和并购 - 公司在高皮质醇症领域拥有深厚的市场理解和经验丰富的团队[23] 未来展望 - Relacorilant组在22周内的收缩压(SBP)平均改善为6.6 mm Hg，p值为0.012[42] - Relacorilant组在22周内的体重减轻为3.9 kg，p值为0.0001[42] - 在延续研究的第24个月，患者的平均收缩压(SBP)显著降低10.0 mm Hg，p值为0.012[47] - 在延续研究的第24个月，患者的平均舒张压(DBP)显著降低7.3 mm Hg，p值为0.016[47] - Relacorilant与nab-paclitaxel联合使用时，疾病进展风险降低30%，中位无进展生存期(PFS)为6.5个月，相较于单独使用nab-paclitaxel的5.5个月[62] - Relacorilant与nab-paclitaxel联合使用时，死亡风险降低31%，中位总生存期(OS)为16.0个月，相较于单独使用nab-paclitaxel的11.5个月[62]

Corcept Therapeutics (CORT) Q1 2025 Earnings Call May 05, 2025 05:00 PM ET Company Participants Atabak Mokari - Chief Financial OfficerSean Maduck - President of EndocrinologyCharles Robbins - Chief Business OfficerJoseph Belanoff - Chief Executive Officer, President and DirectorRoberto Vieira - President - OncologyWilliam Guyer - Chief Development Officer Conference Call Participants Edward Nash - MD & Senior Biotechnology AnalystDavid Amsellem - Sr. Research AnalystJoon Lee - Director & Senior Biotech Ana ...

Corcept Therapeutics (CORT) Q1 2025 Earnings Call May 05, 2025 05:00 PM ET Speaker0 Thank you for standing by and welcome to Corcept Therapeutics First Quarter twenty twenty five Earnings Conference Call. At this time, all participants are in a listen only mode. After the speaker presentation, there will be a question and answer session. To a question during the session, will need to press 11 on your telephone. To remove yourself from the queue, you may press 11 again. I would now like to hand the call over ...

Corcept Therapeutics, Inc. (NASDAQ:CORT) Q4 2024 Earnings Conference Call February 26, 2025 5:00 PM ET Company Participants Atabak Mokari - CFO & Treasurer Gary Robb - Chief Business Officer & Secretary Joe Belanoff - Co-Founder, President, CEO & Director Bill Guyer - Chief Development Officer Sean Maduck - President, Endocrinology Conference Call Participants David Amsellem - Piper Sandler Swayampakula Ramakanth - H.C. Wainwright Asim Rana - Truist Operator Thank you for standing by, and welcome to Corcept ...