Exhibit 1.1 Oruka Therapeutics, Inc. (a Delaware Corporation) 9,660,000 Shares of Common Stock UNDERWRITING AGREEMENT April 28, 2026 Leerink Partners LLC TD Securities (USA) LLC Goldman Sachs & Co. LLC Stifel, Nicolaus & Company, Incorporated Guggenheim Securities, LLC as Representatives of the several Underwriters c/o Leerink Partners LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 c/o TD Securities (USA) LLC 1 Vanderbilt Avenue New York, New York 10017 c/o Goldman Sachs & Co. LLC 200 West S ...