Accessibility StatementSkip Navigation -In head-to-head non-human primate (NHP) studies, average observed half-life of ASC36 was approximately 15 days, 3-fold longer than petrelintide, which supports once-monthly subcutaneous (SQ) dosing in humans. -ASC36 demonstrated approximately 91% greater relative body weight reduction compared to petrelintide in a head-to-head diet-induced obese (DIO) rat study. -ASC36 has excellent chemical and physical stability with no fibrillation around neutral pH, allowing for c ...

Accessibility StatementSkip Navigation Abstract Title: GLP-1R/GIPR Peptide Agonist ASC31 + ASC47 Shows 119.6% More Weight Loss than Tirzepatide in DIO Mice Presentation Time:Â November 4, 2025, 7:30 p.m.-8:30 p.m., EST "We're excited to present the continued progress of our robust obesity portfolio, including both small molecules and peptides at ObesityWeek," said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis. "These advancements reflect our strong determination to develop highly differentiat ...

Accessibility StatementSkip Navigation HAMILTON, Bermuda, Oct. 22, 2025 /PRNewswire/ -- Ardmore Shipping Corporation (NYSE: ASC) ("Ardmore" or the "Company") today announced that the Company plans to announce its third quarter earnings before the market opens Wednesday, November 5, 2025 and will host a conference call later in the day at 10:00 a.m. Eastern Time. The conference call and slide presentation will also be broadcast live over the Internet. Conference Call and Webcast Details: If you are unable to ...

With a professional background spanning multiple industries, from logistics, construction to retail, I bring a diverse perspective to investing. My international education and career experiences have provided me with a global outlook and the ability to analyze market dynamics from different cultural and economic perspectives. I have been actively investing for over a decade, honing a strategy that focuses on cyclical industries while maintaining a diversified portfolio that includes bonds, commodities, and ...

, /PRNewswire/ -- Ascletis Pharma Inc. (HKEX: 1672, "Ascletis") announces today that it recently completed the pre-New Drug Application (NDA) consultation with China National Medical Products Administration (NMPA) for denifanstat (ASC40) for the treatment of moderate-to-severe acne vulgaris and plans to submit an NDA soon. The pre-NDA consultation was initiated from June 2025 and completed in October 2025. - Denifanstat (ASC40) met all primary, key secondary and secondary efficacy endpoints (ITT analysis) ...

British online fashion retailer ASOS warned on Tuesday that annual revenue would come in below market expectations, citing subdued consumer demand and a slow recovery in its fast-fashion business. ...

-        The g astrointestinal ( GI ) tolerability of ASC47 in combination with semaglutide was significantly better than placebo in combination with semaglutide (semaglutide monotherapy).  The incidence of vomiting was 6.7% in ASC47 in combination with semaglutide group compared to  57.1% in the semaglutide monotherapy group. ...

核心观点 - Denifanstat (ASC40) 在治疗中重度痤疮的III期临床试验中达成所有主要、关键次要及次要疗效终点 并展现出良好的安全性与耐受性特征[1][4][11] - 公司正与中国国家药品监督管理局进行新药上市申请前咨询 计划在完成咨询后提交Denifanstat (ASC40)的上市申请[2][11] 临床试验设计 - 该III期临床试验为随机、双盲、安慰剂对照、多中心临床研究 在中国招募480名中重度痤疮患者 按1:1比例随机分配至Denifanstat组(50mg 每日一次口服)或安慰剂组 治疗周期为12周[4] - 主要终点包括治疗成功率(IGA评分达到0或1且较基线下降至少2分)、总皮损计数(TLC)较基线变化百分比及炎症性皮损计数(ILC)较基线变化百分比[5][8] 疗效结果 - 治疗4周后 Denifanstat组在多个疗效终点上已显示出统计学显著改善(p<0.05) 包括治疗成功率、TLC、ILC及非炎症性皮损计数(NILC)[6] - 治疗12周后 Denifanstat组治疗成功率达33.17% 显著高于安慰剂组的14.58%(p<0.0001)[6] - TLC较基线减少百分比达57.38% 显著高于安慰剂组的35.42%(p<0.0001)[6] - ILC较基线减少百分比达63.45% 显著高于安慰剂组的43.21%(p<0.0001)[6] - NILC较基线减少百分比达51.85% 显著高于安慰剂组的28.94%(p<0.0001)[6] 安全性特征 - Denifanstat组治疗期间不良事件(TEAEs)发生率为58.6% 与安慰剂组的56.3%相当[1][9] - 大多数TEAEs为轻度(1级)或中度(2级) 无药物相关的3级或4级TEAEs 无药物相关的严重不良事件(SAEs) 无死亡报告 无因药物导致的永久性治疗中止或退出[9] - 发生率超过5%的TEAEs包括皮肤干燥(6.3% vs 2.9%)和干眼症(5.9% vs 3.8%)[9] 公司背景与合作协议 - Ascletis Pharma Inc是一家专注于代谢疾病治疗药物开发与商业化的生物技术公司 利用其专有人工智能辅助结构基于药物发现平台(AISBDD)和超长效平台(ULAP)开发了多个候选药物[13] - 公司从Sagimet Biosciences Inc获得Denifanstat (ASC40)在大中华区的独家权利[12] 数据发布与行业活动 - III期研究结果于2025年9月17日在欧洲皮肤病与性病学会(EADV)年会最新突破性新闻环节进行口头报告[3] - 详细数据可在公司网站获取[10]

效率比率定义与重要性 - 效率比率是衡量公司财务健康状况的指标 用于分析公司内部资产和负债的使用效率[1] - 该指标有助于评估公司的运营效率水平 但有时难以直接测量 因此需结合多种比率进行股票筛选[1] 关键效率比率指标 - 应收账款周转率：计算方式为12个月销售额除以四个季度平均应收账款 反映公司信贷扩展和收债能力 高比率表明公司收账能力强或客户质量高[2] - 资产利用率：计算方式为过去12个月总销售额除以四个季度平均总资产 体现公司将资产转化为产出的能力 高比率通常代表更高效率[3] - 库存周转率：计算方式为12个月销售成本除以四个季度平均库存 显示公司库存管理能力 高比率表明库存水平相对销售成本较低 低比率则可能预示销售下滑导致库存积压[4] - 营业利润率：计算方式为过去12个月营业收入除以同期销售额 衡量公司控制运营费用的能力 高比率意味着运营效率优于同行[5] 筛选标准与结果 - 采用Zacks排名第一（强力买入）评级作为附加筛选条件[6] - 要求所有效率比率指标必须高于行业平均水平[7] - 从7,906只股票中最终筛选出18只合格标的 其中5只表现最佳[7] 入选公司具体数据 - Post Holdings（POST）：消费品控股公司 主营仓储中心、冷藏、食品服务、食品配料和便利营养产品 四季平均盈利惊喜达21.4%[7] - BuildABear Workshop（BBW）：提供自制毛绒动物互动零售娱乐体验的全国性企业 四季平均盈利惊喜达21.3%[9] - Equity Bancshares（EQBK）：主要向企业、企业主和个人提供金融服务 四季平均盈利惊喜达17.9%[10] - Ardmore Shipping（ASC）：从事产品和化学品油轮的所有与运营 四季平均盈利惊喜达9.6%[11] - Sally Beauty（SBH）：国际专业美容用品零售商和分销商 四季平均盈利惊喜达8.3%[12]

融资进展 - 公司获得非经纪私募配售首轮融资138,500加元 该笔资金属于100万加元总融资计划的首部分[1] - 以每股0.05加元价格发行277万股单位 每个单位包含1股普通股和1份认股权证[2][3] - 认股权证行权价为0.10加元 有效期自融资完成日起一年[3] 资金用途 - 90,000加元用于审计费用 15,000加元用于会计费用 15,000加元用于法律费用[4] - 8,500加元用于申报费用 10,000加元用于一般行政管理费用[4] - 资金将专门用于完成2024年度审计及2025年Q1、Q2未审计财务报表的申报工作[4] 监管状态 - 公司目前受阿尔伯塔证券委员会发出的未申报停牌令(FFCTO)限制[2] - 已向ASC申请部分撤销FFCTO以完成首轮融资交割[2] - 待FFCTO解除后 公司将按原条款完成剩余融资[4] 业务定位 - 公司为自然资源勘探开发企业 当前专注于津巴布韦金矿项目开发[5] - 管理层认为当前高金价环境有利于公司黄金项目发展[5]