合作进展 - 合作伙伴BioAge Labs启动BGE-102的1期临床研究 该药物是一种新型口服小分子NLRP3抑制剂 由HitGen的DNA编码库(DEL)技术平台筛选出的先导化合物开发而成 [1][2][6] - BGE-102临床启动触发合作协议中未披露金额的里程碑付款 [1][6] - 双方自2021年4月宣布成功识别先导分子 2024年2月在《生物有机与药物化学通讯》联合发表研究成果 并提交共同专利覆盖DEL筛选发现的结构新颖化合物 [3] 技术平台优势 - HitGen的DEL技术平台包含超过1.2万亿个小分子 筛选效率支持全球多家机构的药物发现项目 [4] - 平台结合人工智能和自动化DMTA循环 加速临床前候选化合物优化 [5] - 技术应用范围涵盖小分子药物、核酸药物、蛋白降解疗法等领域 [5] 药物特性与适应症 - BGE-102具有高效力和脑渗透性 针对NLRP3靶点开发 该靶点是年龄相关炎症的关键驱动因素 涉及神经退行性疾病、心血管疾病及肥胖等代谢紊乱疾病 [2][7] - 临床前数据显示BGE-102作为单药或与GLP-1受体激动剂联用均能显著减轻体重 [7] - BioAge同步开发长效注射剂和口服小分子APJ激动剂用于肥胖治疗 [7] 商业合作模式 - HitGen通过多样化商业模式与全球数百家生物制药研究机构建立合作 多个项目处于早期发现至临床试验阶段 [5] - 合作案例证明DEL尖端筛选技术与人类衰老生物学洞察结合的价值 [4]

Founder of Dividend Mantra. Founder of Mr. Free At 33. Co-Founder of Dividends & Income. I started blogging about my journey to financial independence back in 2011. By living well below my means and intelligently investing my hard-earned capital, I went from below broke at age 27 to financially free at 33 years old. I regularly create content on dividend growth investing, living off of dividends, undervalued high-quality dividend growth stocks, high-yield situations, and other long-term investment opportuni ...

Good Morning Traders! Today’s economic calendar launches the week on Monday, September 15, 2025, with a very light schedule that may not generate significant market momentum at the outset. At 8:30 AM ET, the Empire Manufacturing data for September was released, offering a regional snapshot of industrial activity, though its impact is typically modest. At 11:30 AM ET, the Treasury's 3-Month and 6-Month Bill Auction will assess short-term debt demand, potentially causing minor yield adjustments but lacking ma ...

MIDLAND, Texas--(BUSINESS WIRE)--Permian Resources Corporation ("Permian Resources†or the "Company†) (NYSE: PR) today announced the pricing of an underwritten public offering of an aggregate 46,112,899 shares of its Class A Common Stock, par value $0.0001 per share ("Class A common stock†), at a price to the public of $13.53 per share, by certain affiliates of Pearl Energy Investments and Riverstone Investment Group LLC (collectively, the "Selling Stockholders†). Permian Resources will not sel. ...

Brown Capital Management, an investment management company, released its “The Brown Capital Management Small Company Fund” second quarter 2025 investor letter. A copy of the letter can be downloaded here. The small-cap US stocks rebounded in the second quarter following a challenging first quarter. The Small Company Fund returned 8.59% in the second quarter, lagging the Russell 2000® Growth index’s 11.97% return. The underperformance in the quarter occurred in the last few weeks of the period. In addition, ...

CoreWeave said on Monday it had signed a new order with Nvidia with an initial value of $6.3 billion, which guarantees that Nvidia will purchase any residual cloud capacity not sold to customers. ...

If you want full access to all our reports, data and investing ideas, join The Aerospace Forum , the #1 aerospace, defense and airline investment research service on Seeking Alpha, with access to evoX Data Analytics, our in-house developed data analytics platform.In my prior report on AerCap Holdings N.V. (NYSE: AER ), I assigned a long-term $158.50 price target to AerCap stock, which would imply 37% upside. Since then, the stock has performed in line with the S&P 500, gaining 5.2%. In this report, IDhierin ...

Fed's going to kick off its two-day policy meeting tomorrow. Joining us now, former Federal Reserve Board nominee, Judy Shelton. She's a senior fellow at the Independent Institute and a former economic adviser to President Trump in his first term.It's good to see you, Judy. It's been a while. Uh it's I'm reading one of your opeds from right when the election happened and you said, "Now that Donald Trump is the president-elect, expect warnings about the dangers of compromising the independence of the Federal ...

If you want full access to all our reports, data and investing ideas, join The Aerospace Forum , the #1 aerospace, defense and airline investment research service on Seeking Alpha, with access to evoX Data Analytics, our in-house developed data analytics platform.In my prior report on AerCap Holdings N.V. (NYSE: AER ), I assigned a long-term $158.50 price target to AerCap stock, which would imply 37% upside. Since then, the stock has performed in line with the S&P 500, gaining 5.2%. In this report, IDhierin ...

Brown Capital Management, an investment management company, released its “The Brown Capital Management Small Company Fund” second quarter 2025 investor letter. A copy of the letter can be downloaded here. The small-cap US stocks rebounded in the second quarter following a challenging first quarter. The Small Company Fund returned 8.59% in the second quarter, lagging the Russell 2000® Growth index’s 11.97% return. The underperformance in the quarter occurred in the last few weeks of the period. In addition, ...