AUSTIN, Texas and NEW YORK, Nov. 05, 2025 (GLOBE NEWSWIRE) -- T1 Energy Inc. (NYSE: TE) (“T1,” “T1 Energy,” or the “Company”) announced this morning that the Company has rescheduled its third quarter earnings release and conference call to November 14, 2025. The third quarter 2025 press release will be issued at or around 6:00 am Eastern Daylight Time. The conference call is scheduled to begin at 8:00 am Eastern Standard Time. To access the conference call, listeners should proceed as follows: Click on the ...

Accessibility StatementSkip Navigation PITTSBURGH, Nov. 5, 2025 /PRNewswire/ -- CNX Resources Corporation (NYSE: CNX) today announced that its Board of Directors has appointed Everett Good, the Company's current Vice President of Finance and Treasury, to serve as Chief Financial Officer, effective January 1, 2026. Mr. Good will succeed Alan Shepard, who, as previously announced, will assume the roles of President and Chief Executive Officer and member of the Board of Directors, effective on the same date. ...

Delivered Y/Y Net Sales Growth of 10.4%Drove Y/Y Bookings Growth in Engagement RingsAchieved 45% Y/Y Bookings Growth in Fine JewelryDelivered 57.6% Gross Margin SAN FRANCISCO, Nov. 05, 2025 (GLOBE NEWSWIRE) -- Brilliant Earth Group, Inc. (“Brilliant Earth” or the “Company”) (Nasdaq: BRLT), an innovative, global leader in ethically sourced fine jewelry, today announced financial results for the three and nine months ended September 30, 2025. Third Quarter 2025 Highlights (quarterly period ended September 30, ...

HOUSTON, Nov. 05, 2025 (GLOBE NEWSWIRE) -- MRC Global Inc. (NYSE: MRC) today announced third quarter 2025 results from continuing operations. Third Quarter 2025 Financial Highlights: Sales of $678 million, a 15% decrease compared to the second quarter of 2025Gross profit, as a percentage of sales, of 18.4%Adjusted Gross Profit, as a percentage of sales, of 21.8%Net loss from continuing operations of $9 millionAdjusted EBITDA of $36 million, or 5.3% of salesRevenue backlog of $571 million, an increase of 4%  ...

业务亮点与战略进展 - 公司宣布其与罗氏和基因泰克的合作取得重要进展，交付了第二个神经科学图谱并因此获得3000万美元里程碑付款，这使得公司从所有合作伙伴处获得的前期和里程碑付款总额超过5亿美元 [3][8][12] - 公司内部研发管线取得显著进展，包括REC-617单药剂量递增研究确定了最大耐受剂量，并显示出初步抗肿瘤活性；REC-7735被提名进入开发候选阶段 [6][9][13] - 公司平台Recursion OS 2.0通过整合多模态生物学、精准设计和临床开发中的人工智能，持续推动项目发展 [16] 财务表现与资金状况 - 截至2025年9月30日，公司现金及现金等价物和受限现金为6.671亿美元，较2024年12月31日的6.03亿美元有所增长；在2025年10月9日收到ATM融资净收益3.875亿美元后，现金及现金等价物约为7.85亿美元，预计资金可支撑运营至2027年底 [8][19] - 2025年第三季度总收入为520万美元，较2024年同期的2610万美元下降，主要原因是2024年8月确认了罗氏和基因泰克首个图谱的3000万美元里程碑付款，而第二个3000万美元里程碑付款预计将在2025年第四季度部分确认为收入 [19] - 2025年第三季度研发费用为1.211亿美元，较2024年同期的7460万美元大幅增加，主要驱动因素是收购REC-102全部权利相关的已收购IPR&D支出以及2024年11月与Exscientia的业务合并 [19][20] - 2025年第三季度净亏损为1.623亿美元，而2024年同期净亏损为9580万美元 [25] 研发管线具体进展 - **REC-617 (CDK7抑制剂)**：在ELUCIDATE 1/2期试验中，29名晚期实体瘤患者参与，确定了10 mg每日一次的最大耐受剂量，安全性可控，最常见剂量限制性毒性为恶心和血小板减少，≥3级治疗相关不良事件发生率为27.6%，观察到1例确认的部分缓解和5例疾病稳定 [13] - **REC-7735 (PI3Kα H1047R抑制剂)**：被提名为开发候选药物，正在进行新药临床试验申请所需的研究，临床前研究显示在低剂量下具有显著的肿瘤消退效果，并保持对野生型PI3Kα的高选择性 [13] - **REC-4881 (MEK1/2抑制剂)**：针对家族性腺瘤性息肉病的2期TUPELO研究预计于2025年12月获得更多数据 [13] 合作伙伴关系成果 - **罗氏和基因泰克**：合作已产生6个表型图谱（4个胃肠道肿瘤，2个神经科学），已在18个月内达成4个里程碑，并启动了一个胃肠道肿瘤适应症项目，合作总付款已达2.13亿美元 [4][12][18] - **赛诺菲**：合作专注于肿瘤学和免疫学领域最多15个同类最优或首创项目，目前已达成1.3亿美元的前期和里程碑付款，每个项目潜在里程碑付款超过3亿美元 [18] - **拜耳**和**默克**的合作项目也在持续推进中，分别聚焦于肿瘤学以及肿瘤学和免疫学领域 [4] 近期里程碑展望 - 预计到2026年底前有望获得超过1亿美元的里程碑付款 [13] - REC-1245的早期1期安全性和药代动力学数据预计在2026年上半年获得，REC-3565的相应数据预计在2027年上半年获得 [13] - REC-102和REC-7735的1期试验预计在2026年下半年启动 [13] - 多个项目将在未来12个月内推进至潜在的先导系列和开发候选药物认定阶段 [13][18]

For the three months ended September 30, 2025, from continuing operations: Revenues of $701.3 millionGAAP net loss of $(15.9) millionAdjusted EBITDA of $50.7 millionGAAP and adjusted net (loss) income per diluted share of $(0.17) and $0.12, respectivelyBook-to-bill ratio of 1.13x, resulting in 1.07x book-to-bill for the trailing 12 monthsCost saving initiatives remain on trackRaising 2025 revenue guidance to a range of $2,700 million to $2,750 million; narrowing 2025 adjusted EBITDA guidance to a range of $ ...

Conference Call and Webcast Today at 8:30 a.m. ETPhase 2/3 OCU410ST GARDian3 pivotal confirmatory trial is progressing toward 1H 2027 Biologics License Application (BLA) filing with 50% enrollment completed to date European Medicines Agency (EMA) provided acceptability of a single U.S.-based trial for submission of a Marketing Authorization Application (MAA) Executed licensing agreement with Kwangdong Pharmaceutical for exclusive rights in South Korea to OCU400 Sales milestones of $1.5 million for every $15 ...

核心领导层变动 - 公司宣布自2026年1月1日起生效的领导层过渡计划，联合创始人兼首席执行官Chris Gibson将转任董事会主席，Najat Khan将被任命为首席执行官兼总裁 [1] - 此次任命反映了公司对连续性、协作以及下一阶段发展的共同承诺，包括发展操作系统平台、推进研发管线以及为患者带来变革性药物 [1] - 董事会一致批准此项过渡计划，显示出对Najat Khan战略洞察力及将新科学转化为实际价值的能力充满信心 [2] 新任首席执行官背景与资历 - Najat Khan目前担任首席研发与商务官及董事会成员，拥有有机化学博士学位及麻省理工学院人工智能/机器学习认证 [4][7] - 其在强生创新医药担任首席数据科学官期间，帮助公司将研发管线价值提升三倍，并建立了行业领先的数据科学组织，使强生成为首批在研发组合中战略性扩展人工智能应用的大型药企之一 [6] - 加入公司后，其推动了多项临床项目的优先排序与进展，并主导了公司与Exscientia的合并，该交易是2024年规模最大的TechBio领域并购案 [5] 公司技术平台与战略定位 - 公司是一家临床阶段的TechBio公司，通过解码生物学来改善人类生活，其核心是Recursion操作系统平台，该平台利用多种技术持续生成全球最大的专有生物和化学数据集之一 [8] - 平台利用复杂的机器学习算法，从数据集中提炼出数万亿个可搜索的生物学和化学关系，不受人类偏见限制，并拥有每周进行数百万次湿实验室实验的大规模实验能力，以及全球最强大的超级计算机之一 [8] - 新任首席执行官强调，公司将把平台洞察转化为临床证据，在具有真正优势的领域进行扩展，最终为患者提供变革性药物 [2]

LAS VEGAS, Nov. 05, 2025 (GLOBE NEWSWIRE) -- California-based e-bike brand SPACEVELO energized the 2025 SEMA Show with the debut of its next-generation dual-battery e-bike, the BLITZ S1. Quickly becoming one of the most visited exhibits in the Powersports & Utility Vehicles section, the BLITZ S1 drew impressive attention from media, families, and young riders eager to experience its blend of design, endurance, and freedom. Youth Energy Meets Innovation at SEMAFrom the opening morning, the SPACEVELO booth ( ...

The Acquisition focuses the Top Crypto News Platform to Expand Verifiable News Distribution to Telegram’s 1+ Billion UsersLondon, UK, Nov. 05, 2025 (GLOBE NEWSWIRE) -- AlphaTON Capital Corp ("AlphaTON Capital" or the "Company") (Nasdaq: ATON) – AlphaTON Capital, a leading investment firm focused on disruptive technologies, today announced definitive terms to acquire Blockchain Wire, the industry’s premier press release distribution service for the blockchain, crypto, and digital asset sectors. This strategi ...