AIM ImmunoTech Inc. (AIM) appears an attractive pick, as it has been recently upgraded to a Zacks Rank #1 (Strong Buy). This upgrade is essentially a reflection of an upward trend in earnings estimates -- one of the most powerful forces impacting stock prices.A company's changing earnings picture is at the core of the Zacks rating. The system tracks the Zacks Consensus Estimate -- the consensus measure of EPS estimates from the sell-side analysts covering the stock -- for the current and following years.Ind ...

临床进展 - 公司在2024年取得了多项临床、监管和企业里程碑，特别是在胰腺癌和长新冠领域的关键未满足需求中持续推进Ampligen的临床开发项目 [1][2][7] - 在复发性卵巢癌的2期临床试验中，Ampligen与pembrolizumab联合治疗显示出积极的顶线数据 [5] - 在晚期胰腺癌的DURIPANC 1b/2期研究中，Ampligen与AstraZeneca的Imfinzi联合治疗的首个剂量水平耐受性良好，并报告了积极的初步数据 [8] - 在长新冠疲劳症的2期研究中，Ampligen显示出作为潜在治疗药物的潜力，并计划进行后续临床试验 [9] 知识产权与生产 - 公司在2024年获得了两项重要专利，涵盖Ampligen在子宫内膜异位症和长新冠疲劳症中的应用 [10][17] - 成功完成了9,042瓶Ampligen的cGMP生产，并发布了Ampligen作为联合疗法治疗黑色素瘤的新临床前数据 [10] 未来里程碑 - 预计在未来18个月内，公司将实现多项价值驱动型里程碑，包括多个由美国国家癌症研究所、AstraZeneca和Merck部分资助的临床试验 [7][11][12][13][14][15][16] - 在转移性胰腺导管腺癌的1b/2期研究中，Ampligen与durvalumab联合治疗的研究正在进行中，预计在2025年上半年完成首例患者给药 [11][18] - 在复发性卵巢癌的2期研究中，预计在2025年上半年完成最后一名患者的给药和研究 [14] - 在长新冠疲劳症的2期研究中，预计在2025年第一季度发布最终研究结果 [16] 公司背景 - AIM ImmunoTech Inc 是一家专注于研发治疗多种癌症、免疫疾病和病毒性疾病（包括COVID-19）的免疫制药公司，其主导产品Ampligen是一种首创的TLR3激动剂免疫调节剂 [19]

Plantible is a vertically integrated biology company unlocking the potential of duckweed to create a plant-based protein that emulates the characteristics of animal-based proteins CH4 Global is scaling up production of Asparagopsis seaweed to reduce enteric methane emissions from cattle, a key driver of climate change NEWPORT BEACH, Calif., Jan. 15, 2025 /PRNewswire/ -- Chipotle Mexican Grill (NYSE: CMG) today announced it is making minority investments in Plantible, a company harnessing the power of Lemna ...

A Plan for Compliance has been UndertakenOCALA, Fla., Dec. 17, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”), announced today that it received a notice (the “Notice”) from the NYSE American LLC (the “NYSE American”) dated December 11, 2024, notifying the Company that it is no longer in compliance with NYSE American continued listing standards. This is an issue previously disclosed in our most recent Report on Form 10-Q. Specifically, the letter states that the Co ...

OCALA, Fla., Dec. 12, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”) today announced that the Netherlands Patent Office (Octrooicentrum Nederland) has granted Patent No. 2,032,813 — a compositions and methods patent — covering Ampligen® (rintatolimod) for use in the treatment of the post-COVID condition of fatigue. The patent inventors, AIM CEO Thomas K. Equels and AIM Medical Officer David R. Strayer, M.D., have assigned the granted patent to the Company. AIM CEO ...

Follows Announcement Earlier this Week that Ampligen Co-Founder and Former AIM CEO Agreed to Join Scientific Advisory Board if Kellner Group Nominees Are Elected Kellner Group Reiterates Plan to Revitalize AIM, Accelerate Clinical Development and Restore Value for StockholdersKellner Group Urges Stockholders of AIM Immunotech to Vote the Gold Card Kellner Group Owns 5.04% of Outstanding Shares and is Fully Aligned with Stockholders NEW YORK, Dec. 12, 2024 (GLOBE NEWSWIRE) -- Ted Kellner, as the nominating s ...

Incumbent Board’s Claims of Progress Are Not Credible or Supported by DataAIM Maintains Relationship with CRO Co-Founded by a Convicted Felon Who Deceived Investors about the Timeline and Status of Regulatory Submissions to the U.S. FDAAccording to ISS – “The lack of transparency gives the impression that the company’s pipeline is more advanced and that the company is more involved than it actually is”1 Kellner Group Owns 5.04% of Outstanding Shares and is Fully Aligned with StockholdersKellner Group Urges ...

Kellner Group Has Financial Resources AIM Needs Kellner Group Owns 5.04% of Outstanding Shares and is Fully Aligned with Stockholders AIM Cash Conservation Plan is Too Little Too Late, Exposes Desperate Financial Condition AIM Stock Price has Declined 99+% Frantic AIM Board Doubles Down on Attempts to Deceive Stockholders NEW YORK, Dec. 02, 2024 (GLOBE NEWSWIRE) -- Ted Kellner, as the nominating stockholder and a nominee, together with his other nominees, Todd Deutsch, Robert L. Chioini and Paul W. Sweene ...

OCALA, Fla., Nov. 19, 2024 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”) today announced that data were published on Roswell Park Comprehensive Cancer Center’s Phase 1 study evaluating AIM ImmunoTech’s drug Ampligen® (also known as rintatolimod) as a component of a chemokine-modulating (CKM) regimen in early-stage triple-negative breast cancer (TNBC). Results of the study were reported in The Journal for ImmunoTherapy of Cancer. “We are very excited with these promisi ...

财务数据和关键指标变化 - 公司正在协商490万美元的应付账款，同时有一家D&O保险公司未支付250万美元的二级保险费用，这对公司的持续经营和股东权益有重要影响[8] 各条业务线数据和关键指标变化 - 在胰腺癌业务方面，DURIPANC试验1b/2期研究中200毫克剂量的Ampligen被认为是安全的，已进入400毫克剂量阶段，研究遇到一些筛选失败问题，还需至少一名患者入组以完成1b期研究，目前在200毫克和400毫克剂量下尚未出现严重不良事件，在3个月评估时间点，6名患者中有5名病情稳定，相比历史数据有显著提升，初步的无进展生存期数据显示联合用药有一定优势，预计2025年第一季度进入2期研究[10] - 在AMP - 270试验中，已根据与FDA的讨论修改了方案并提交给FDA征求意见，目前clinicaltrials.gov已更新，方案已获得IRB批准，正在向各站点传播新方案以开始招募患者，但由于预算等问题难以预测第一名患者的入组时间[11] - 在卵巢癌业务方面，一项联合治疗晚期复发性卵巢癌的试验将提前结束，患者人数从45人减少到30人，目前正在收尾入组工作，希望在年底前提交相关数据的手稿进行同行评审，另一项2期研究正在招募第一名患者[12] - 在新冠后疲劳症状的业务方面，最终的完整研究报告已获批准，11月底将在clinicaltrials.gov上公布数据，正在研究生物标志物数据以确定最佳的入组人群[13] 各个市场数据和关键指标变化 - 子宫内膜异位症市场2023年估计为24亿美元，预计到2032年将达到37亿美元[7] 公司战略和发展方向和行业竞争 - 公司的主要战略是推动Ampligen获得批准，强调与大型制药公司的合作和商业化机会，不断积累临床数据，扩大知识产权组合以增加公司作为合作伙伴或收购目标的吸引力[7][9] - 在生产方面，与Sterling Pharma Solutions合作优化Ampligen的生产流程，减少了约40%的聚合物生产时间，降低了成本，并且还有进一步提高效率的计划[15][27] - 公司面临着来自激进投资者的挑战，他们提名了四个人来取代公司整个董事会，但公司现任董事认为如果激进投资者控制董事会，公司的进展和势头将受到威胁，公司的现金状况可能会严重受损[19] 管理层对经营环境和未来前景的评论 - 公司在多个适应症方面的数据不断增长，这是积极的，整个团队致力于帮助有需要的患者并为股东创造价值[17] 其他重要信息 - 公司已向SEC提交了2024年年度股东大会的最终委托声明和相关委托材料，鼓励股东仔细阅读[18] 问答环节所有的提问和回答 问题: 能否提供更多关于新冠后项目的下一步计划以及潜在的后续研究情况 - 公司正在利用刚刚完成分析的数据来制定下一次试验的纳入标准，在RECOVER - TLC项目中，如果Ampligen被选中，大部分临床设计将由NIH主导，如果未被选中，公司将针对最严重、中重度且具有特定生物标志物的患者设计2/3期试验，重点关注疲劳或运动后不适等结果[21][22][23] 问题: 提到能够降低Ampligen的生产批次成本和时间，那么具体成本和时间是多少，是否有进一步改进的机会 - 目前聚合物生产过程中，每批Poly I和Poly C12U的成本从约40万美元降低到约20万美元，公司有计划将聚合物生产转变为连续流过程，这可能会使Ampligen的批次产量从约9500瓶增加到约30000 - 35000瓶，成本降低约60% - 70%，并且公司还有继续提高生产效率的计划[26][27][28]