Completed enrollment in soquelitinib atopic dermatitis Phase 1 trial extension cohort 4 (200 mg BID dose with 8-week treatment period) with data announcement anticipated in January Soquelitinib atopic dermatitis phase 2 trial on track to initiate in early Q1 2026 Phase 3 registrational clinical trial of soquelitinib in relapsed/refractory peripheral T cell lymphoma (PTCL) enrolling with multiple clinical sites open; final Phase 1/1b results accepted for oral presentation at the American Society of Hematolog ...

About this content About Angela Harmantas Angela Harmantas is an Editor at Proactive. She has over 15 years of experience covering the equity markets in North America, with a particular focus on junior resource stocks. Angela has reported from numerous countries around the world, including Canada, the US, Australia, Brazil, Ghana, and South Africa for leading trade publications. Previously, she worked in investor relations and led the foreign direct investment program in Canada for the Swedish government ...

CTX-10726 demonstrated potent, simultaneous inhibition of tumor angiogenesis and PD-1-mediated immune suppression, and eliminated tumors in multiple preclinical studies.In vivo, CTX-10726 outperformed select competitive antibodies in the class, including ivonescimab, in controlling tumor growth across multiple xenograft and syngeneic models.IND submission is on track for Q4 2025. BOSTON, Nov. 04, 2025 (GLOBE NEWSWIRE) -- Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharma ...

Accessibility StatementSkip Navigation PHILADELPHIA, Nov. 3, 2025 /PRNewswire/ -- National plaintiffs' law firm Berger Montague PC announces a class action lawsuit against MoonLake Immunotherapeutics (NASDAQ: MLTX) ("MoonLake" or the "Company") on behalf of investors who purchased MoonLake shares during the period of March 10, 2024 through September 29, 2025 (the "Class Period"). Investor Deadline: Investors who purchased MoonLake securities during the Class Period may, no later than December 15, 2025, ...

BioNTech (NasdaqGS:BNTX) Q3 2025 Earnings Call November 03, 2025 08:00 AM ET Company ParticipantsManoj Eradath - Senior Biotechnology Equity ResearcherUğur Şahin - CEODouglas Maffei - Vice President of Strategy and Investor RelationsRamón Zapata - CFOÖzlem Türeci - CMO and Co-FounderConference Call ParticipantsMalcolm Hoffman - AnalystYaron Werber - Senior Biotechnology AnalystDaina Graybosch - AnalystNone - AnalystTerence Flynn - Equity Research AnalystNic Jennings - AnalystMohit Bansal - AnalystJay Olson ...

SOUTH SAN FRANCISCO, Calif., Nov. 03, 2025 (GLOBE NEWSWIRE) -- Corvus Pharmaceuticals, Inc. (NASDAQ: CRVS), a clinical-stage biopharmaceutical company, today announced that final data from its Phase 1/1b trial of soquelitinib in patients with T cell lymphoma will be presented in an oral session at the 67th American Society of Hematology (ASH) Annual Meeting & Exposition, which is taking place December 6-9, 2025 in Orlando, FL. Details regarding the oral presentation are as follows: Session Name: 625. T Cell ...

BioNTech (NasdaqGS:BNTX) Q3 2025 Earnings Call November 03, 2025 08:00 AM ET Company ParticipantsManoj Eradath - Senior Biotechnology Equity ResearcherUğur Şahin - CEODouglas Maffei - Vice President of Strategy and Investor RelationsRamón Zapata - CFOÖzlem Türeci - CMO and Co-FounderConference Call ParticipantsMalcolm Hoffman - AnalystYaron Werber - Senior Biotechnology AnalystDaina Graybosch - AnalystNone - AnalystTerence Flynn - Equity Research AnalystNic Jennings - AnalystMohit Bansal - AnalystJay Olson ...

BioNTech (NasdaqGS:BNTX) Q3 2025 Earnings Call November 03, 2025 08:00 AM ET Speaker0Welcome to BioNTech's third quarter 2025 earnings call. I will now hand the call over to Doug Maffei, Vice President, Strategy and Investor Relations. Please go ahead.Speaker2Thank you, Operator. Good morning and good afternoon, everybody. Thank you for joining BioNTech's third quarter 2025 earnings call. As a reminder, the slides we'll use during the call and the corresponding press release can be found in the investor sec ...

OCALA, Fla., Nov. 03, 2025 (GLOBE NEWSWIRE) -- AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”) today announced that the European Patent Office has officially granted AIM’s European Patent No. 4,096,675, titled “Compositions for Treating LONG COVID,” covering compositions of matter of AIM’s proprietary dsRNAs including, for example, Ampligen® (rintatolimod) for use in the treatment of Long COVID. “While AIM’s immediate and primary focus is to build upon the continued positive results from o ...

涉及的行业或公司 * 公司为Intensity Therapeutics Inc (NasdaqCM: INTS) [1] * 行业为生物制药行业 专注于肿瘤免疫治疗领域 [4][5] 核心观点和论据 **技术平台与药物机制** * 公司核心技术为分子转运技术 核心药物候选物为INT230-6 [5] * INT230-6由三种成分组成 包括SHAU（一种新型分子）以及两种强效细胞毒性药物 cisplatin 和 vinblastine [5][6] * SHAU分子是技术关键 能使药物成分同时溶于脂肪和水 从而在瘤内注射后实现药物在整个肿瘤内的扩散和细胞渗透 而非仅停留在注射点 [6][7][8] * 临床前研究表明 该药物不仅能在局部杀死癌细胞 还能刺激免疫系统 产生全身性的抗癌免疫反应 [8][9] **临床研究设计与安全性** * 公布的IT-01研究是一项评估INT230-6在转移性难治性实体瘤患者中的I期研究 [10] * 研究采用3+3+3剂量递增设计 共有6个单药治疗队列 最终确定单次给药最大安全体积为175毫升 [11][13][14] * 给药剂量基于患者肿瘤体积进行个性化定制 而非固定剂量 [9][10] * 药代动力学数据显示 瘤内给药后 95%或以上的药物成分（如vinblastine）保留在肿瘤内 系统暴露量极低 这与临床前数据一致 [15] * 药物总体耐受性良好 无剂量限制性毒性 最常见的治疗相关不良事件为注射部位疼痛 疲劳和短暂轻度恶心 无4级或5级不良事件 [16] * 与cisplatin和vinblastine的系统给药相比 INT230-6的毒性特征非常有利 [16][17] **疗效结果** * 在所有接受单药治疗的患者中 疾病控制率（DCR）为75%（其中部分缓解PR为2例 疾病稳定SD为72%）[18] * 探索性分析显示 当注射的肿瘤负荷占患者总肿瘤负荷≥40%时 DCR提高至83% 而注射负荷<40%时 DCR为50% 部分缓解仅出现在注射负荷≥40%的患者中 [19] * 所有64名患者的中位总生存期（mOS）约为12个月 优于历史报道的同类实体瘤I/II期研究中系统性化疗的mOS（约4-7个月）[22][23][30] * 注射肿瘤负荷≥40%的患者 mOS显著延长至18.7个月 而注射负荷<40%的患者mOS仅为3个月 [23] * 在肉瘤患者亚组（n=15）中 mOS为21个月 其中注射负荷≥40%的患者中位生存期在数据截止时尚未达到 [24][25] * 生存超过21个月的15名患者均为经过多重预治疗的患者 中位既往治疗线数为4 [25][26] * 在约20%的注射负荷≥40%的患者中观察到未注射肿瘤的缩小 表明产生了全身性（远隔）抗肿瘤效应 [28][29] * 治疗前后活检显示 肿瘤内癌细胞（紫色染色）显著减少 同时CD4和CD8阳性T细胞等免疫细胞大量浸润肿瘤微环境 [26][27] 其他重要内容 **研究局限性与未来计划** * 研究为单臂I期试验 存在患者数量有限 影像学评估频率不一致 后续治疗影响未知 肿瘤类型和负荷异质性大等局限性 [31][32] * 公司已有一个针对三种肉瘤亚型的III期研究方案获得八个国家监管机构批准 但因资金问题暂停 重启需约2500万美元资金 [40][41] * 另有与抗PD-1和抗CTLA-4抗体联合治疗的两个队列已完成患者入组 但未包含在此次发表的论文中 计划未来另行发表 [44][45][46] **市场与融资动态** * 公司在会议当天宣布获得来自一家知名机构投资者的融资 被视为积极信号 公司正与投行洽谈 寻求通过合作或融资为III期研究获取资金 [41][42]