Company Urges Stockholders to Vote ‘FOR’ Reverse Stock Split Proposal at Upcoming Annual Meeting to Avoid Nasdaq Delisting Leading Independent Proxy Advisory Firms, ISS and Glass Lewis, Support Proposal #2 SOUTH SAN FRANCISCO, Calif., May 16, 2025 (GLOBE NEWSWIRE) -- Vaxart, Inc. (Nasdaq: VXRT) today announced that it has filed a supplement to its proxy statement for its Annual Meeting. The board of directors approved the following two items, if Proposal #2 passes: The current authorized number of shares of ...

"We are pleased to receive BARDA approval to move forward with dosing in this large-scale study and expect to dose the first patient in this cohort in the second quarter of 2025," said Steven Lo, Chief Executive Officer of Vaxart. "We are deeply grateful for the continued support of our government partners at HHS and BARDA, whose collaboration is critical to advancing our clinical development program." The Phase 2b trial is a double-blind, multi-center, randomized, comparator-controlled study. It is designe ...

Challenge Study measured safety, efficacy against infection and symptomatic disease as well as viral shedding Machine learning analyses identified statistically significant correlates of protection and will be incorporated into the development of Vaxart’s second-generation norovirus vaccine candidate, which is being evaluated in a Phase 1 clinical trial SOUTH SAN FRANCISCO, Calif., May 14, 2025 (GLOBE NEWSWIRE) -- Vaxart, Inc. (Nasdaq: VXRT) today announced the publication of complete data from a Phase 2b ...

Vaxart (VXRT) Q1 2025 Earnings Call May 13, 2025 04:30 PM ET Company Participants Edward Berg - Senior Vice President and General CounselSteven Lo - CEO , President & DirectorJames Cummings - Chief Medical OfficerSean Tucker - Founder & Chief Scientific OfficerPhillip Lee - Chief Financial OfficerCheng Li - Director - Equity ResearchMayank Mamtani - Senior Managing Director & Group Head of HealthcareLiang Cheng - Senior Research Associate Operator Greetings. Welcome to Vaxart Business Update and First Quart ...

Vaxart (VXRT) Q1 2025 Earnings Call May 13, 2025 04:30 PM ET Speaker0 Greetings. Welcome to Vaxart Business Update and First Quarter twenty twenty five Financial Results Conference Call. A question and answer session will follow management's opening remarks. Individual investors may submit written questions to vaxart.com. As a reminder, this conference is being recorded. I would now like to turn the webcast over to your host, Ed Berg, Senior Vice President and General Counsel. Speaker1 Good afternoon, and w ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Vaxart, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 59-1212264 (State or other jurisdiction of incorporation or organization) (IRS Employer Identification No.) 170 Harbor Way, Suite 300, South San Francisco, For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT ...

Actively screening for the 10,000 participant portion of COVID-19 Phase 2b trial; Dosing expected to begin in second quarter of 2025 Completed enrollment of Phase 1 clinical trial evaluating Company’s second-generation oral norovirus vaccine constructs, with topline data expected in mid-2025 New avian influenza vaccine candidate was 100% protective in a ferret challenge model, compared with 0% survival in placebo-treated animals Jeroen Grasman appointed as Chief Financial Officer effective May 19, 2025 Cash ...

- Mr. Grasman brings over two decades of biotech financial leadership experience - SOUTH SAN FRANCISCO, Calif., May 13, 2025 (GLOBE NEWSWIRE) -- Vaxart, Inc. (Nasdaq: VXRT) today announced the appointment of Jeroen Grasman as its Chief Financial Officer (CFO), effective May 19, 2025. Mr. Grasman succeeds Phillip Lee, who is resigning from his position as CFO for personal reasons. To ensure a smooth transition, Mr. Lee will remain with the Company as a non-executive employee through June 1, 2025. “We are del ...

Company Urges Stockholders to Vote FOR Reverse Stock Split Proposal at Upcoming Annual Meeting to Avoid Nasdaq Delisting SOUTH SAN FRANCISCO, Calif., May 12, 2025 (GLOBE NEWSWIRE) -- Vaxart, Inc. (Nasdaq: VXRT) today addresses frequently asked stockholder questions regarding a reverse stock split proposal at the Company’s Annual Meeting taking place on Wednesday, May 21, 2025, to regain Nasdaq compliance. 1) Why is Vaxart proposing a reverse stock split? a. Vaxart is at risk of being delisted from Nasdaq si ...

纪要涉及的行业和公司 - 行业：疫苗行业 - 公司：Vaxart (VXRT) 纪要提到的核心观点和论据 公司优势 - **疫苗递送方式变革**：公司致力于改变疫苗递送方式，采用口服药丸疫苗平台，无需注射，简化了接种流程，节省时间，还能减少注射相关的副作用和不便，如无需预约、排队等待医护人员注射等[3][4][7][8]。 - **免疫反应优势**：口服疫苗不仅能提供全身性免疫，还能促进黏膜免疫，产生的二聚体IgA能在病原体感染细胞前提供额外防御，且对病原体变异有一定应对能力，优于传统注射疫苗主要产生的系统性IgG反应[15][16][17]。 - **技术平台优势**：公司的VaST技术平台由非复制性AD5、病原体特异性抗原和佐剂组成，口服后能在小肠下部激活免疫系统，具有良好的安全性和耐受性，且热稳定性好，无需复杂冷链，便于储存和运输[14][15][11][28]。 - **研发和生产优势**：公司创始人是黏膜免疫专家，拥有强大的知识产权，支持口服重组药丸疫苗；公司位于南旧金山生物科技中心，在美国本土进行生产，且团队成员经验丰富[12][13]。 产品管线 - **诺如病毒疫苗** - **市场需求大**：诺如病毒感染普遍，全球每年有超6.8亿感染病例，美国有2000万临床病例，全球每年超20万死亡病例，美国超900例死亡和10万例住院病例，经济成本高，全球每年600亿美元，美国每年100亿美元[21][22]。 - **目标人群广**：包括老年人、免疫功能低下者、医疗机构人员、军人、食品工作者、儿童保育人员、哺乳期母亲、旅行者等[23][24][25][26]。 - **产品特点**：二价疫苗包含G11和G24两种毒株，能提供持久、交叉反应和黏膜免疫，减少病毒 shedding，降低疾病传播；采用先进重组技术制造，可扩展、易给药、室温稳定、可快速开发和全球供应[27][28][29][30][31]。 - **临床数据**：已显示出系统性和黏膜免疫反应，能减少病毒 shedding 80%；正在进行第一代和改进后疫苗的一期头对头试验，预计年中获得顶线数据[32][33][36][47]。 - **新冠疫苗** - **项目进展**：获得BARDA高达4.6亿美元的资助，目前有400人哨兵研究和1万人研究正在进行，哨兵研究已完成招募，预计2025年12月完成临床部分，1万人研究已解除停工令，正在筛选参与者[37][40][42]。 - **产品优势**：符合Project NextGen的多项要求，如易给药、减少病毒传播、更好保护、长效、快速部署和泛冠状病毒保护；已显示出交叉反应和持久免疫反应，新构建体血清反应更好，能增强mRNA疫苗接种者的免疫反应[37][38][39][42][43][44]。 - **流感疫苗** - **临床数据**：2017年进行的人体挑战研究中，与当时美国最流行的流感疫苗Fluzone相比，公司候选疫苗使感染率降低49%，p值为0.001，且能减少病毒 shedding[45][46][47]。 - **项目进展**：有季节性和大流行H5项目正在进行，已在二期研究中证明了保护效力，将继续开发[48]。 其他重要但是可能被忽略的内容 - 公司的诺如病毒疫苗在临床研究中，FDA对公司确定的保护相关性指标要求提供更多信息，但公司认为功能性抗体MbAA和粪便IgA或黏膜免疫对预防诺如病毒有重要意义[33][34]。 - 公司新冠疫苗的10000人研究在2024年4月解除停工令后，正在与BARDA讨论参与者的给药剂量[42]。