股价表现与近期催化剂 - 礼来公司股价在截至10月3日的交易周内飙升16%，达到自4月以来的最高水平 [1] - 股价在8月7日因口服GLP-1药物orforglipron令人失望的临床试验结果而暴跌超过14%，但此后已反弹，年内涨幅超过31% [2] - 股价在9月30日和10月1日分别大幅上涨5%和8%，主要受辉瑞与政府达成关税协议的消息推动，市场预期礼来也能达成类似协议 [4][5] 关税风险与应对策略 - 9月25日宣布的潜在政策是，进口品牌药至美国的公司可能面临100%关税，但投资美国制造设施的公司可获豁免 [3] - 礼来公司为应对2025年可能的高额药品关税已进行智能准备，于2月宣布将增加270亿美元对美国制造业的投资 [6] - 公司首席执行官表示礼来将成为美国注射用GLP-1药物的净出口商，这些因素使其处于达成避税协议的有利位置 [6] 潜在协议的影响分析 - 若仿效辉瑞协议，礼来可能需降低药品价格，但辉瑞的降价承诺主要针对直接面向消费者（DTC）和医疗补助（Medicaid）渠道，这两个渠道合计仅占2023年美国药品销售的24% [7][8] - 医疗补助计划在2024年对Zepbound和Mounjaro的支出合计仅约2亿美元，相对于这两种药物过去12个月超过240亿美元的销售额影响微乎其微 [9] - 礼来公司表示其DTC渠道Lilly Direct仅占Zepbound总处方量的个位数百分比，进一步表明关键市场受到保护 [9] 产品与市场地位 - 礼来是广受欢迎的减肥和糖尿病药物Zepbound和Mounjaro的制造商 [1] - Zepbound和Mounjaro在过去12个月的合并销售额超过240亿美元 [9]

Let's focus in on the t pharma tariff impact with Jared Holes, healthc care strategist at Missouo. Jared, always good to see you. Um, so it was a shrug basically from big cap pharma stocks in terms of the impact.Um, but walk us through some of the impacts on some of the smaller players that may not have US manufacturing. Um, I would think that it would have a much more devastating impact for not the mercs of the world, but maybe sort of the mid and the small caps. >> Yeah, I totally agree.Yeah, I mean that ...

Britain on Friday said it was pressing the United States on pharmaceutical tariffs in hope of a beneficial outcome, after President Donald Trump said a new 100% tariff would apply to firms unless they build a manufacturing presence in the country. ...