– ARV-393 demonstrated significant single-agent activity in models of nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (also known as AITL) and transformed follicular lymphoma – – In combination with small molecule inhibitors, ARV-393 demonstrated enhanced tumor growth inhibition, including tumor regressions, in models of aggressive diffuse large B-cell lymphoma (DLBCL) – NEW HAVEN, Conn., June 13, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company ...

NEW YORK, June 06, 2025 (GLOBE NEWSWIRE) -- Pomerantz LLP is investigating claims on behalf of investors of Arvinas, Inc. (“Arvinas” or the “Company”) (NASDAQ: ARVN). Such investors are advised to contact Danielle Peyton at newaction@pomlaw.com or 646-581-9980, ext. 7980. The investigation concerns whether Arvinas and certain of its officers and/or directors have engaged in securities fraud or other unlawful business practices.  [Click here for information about joining the class action] On May 1, 2025, Arv ...

– This submission is supported by the pivotal Phase 3 VERITAC-2 clinical trial, results of which were recently presented at the 2025 American Society for Clinical Oncology Annual Meeting and published in The New England Journal of Medicine – – VERITAC-2 data support vepdegestrant as a potential treatment option in patients with ESR1m ER+/HER2- advanced or metastatic breast cancer – NEW HAVEN, Conn., June 06, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), today announced the submission of a New Drug ...

Arvinas (ARVN) 2025 Conference June 05, 2025 02:35 PM ET Speaker0 My name is Akash Chewari. I am a pharma and biotech analyst here and we have the Arvenous management team. John, I'm gonna hand it off to you for some I think you have some slides you want to present and then we'll get started with the q and Thank Speaker1 Thanks for being here. I thought I'd start just by setting the scene around Arvinus and giving you a little bit of background of where we are today. So forward looking statements. So Arvinu ...

– Company to showcase preclinical studies of ARV-393, an investigational oral PROTAC BCL6 degrader, as a single agent in models of nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (AITL) and transformed follicular lymphoma, and in combination with small molecule inhibitors in models of diffuse large B-cell lymphoma – NEW HAVEN, Conn., June 05, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company working to develop a new class of drugs based on targete ...

临床试验结果 - Vepdegestrant在VERITAC-2临床试验中显示出5个月的中位无进展生存期（mPFS），相比于Fulvestrant提高了2.9个月[17] - 在VERITAC-2试验中，共有624名患者参与，其中ESR1突变患者为270名[28] - Vepdegestrant组的患者中，31%（96名）仍在接受治疗，而Fulvestrant组为24%（76名）[28] - Vepdegestrant的治疗持续时间中位数为4.2个月，范围为0.1至18.6个月[28] - ESR1突变患者在Vepdegestrant组的中位数为5.1个月，而Fulvestrant组为2.8个月[28] - Vepdegestrant的剂量为每日200毫克，Fulvestrant为每28天500毫克[22] - Vepdegestrant在ESR1突变患者中显示出最佳的治疗潜力，针对约20,000名患者的高未满足需求[17] - Vepdegestrant的临床试验结果支持其作为一线治疗的潜力，计划向FDA提交新药申请[3] - 试验的主要终点为ESR1突变患者的无进展生存期，关键次要终点为总体生存期[22] - Vepdegestrant的独特机制作为PROTAC ER降解剂，使其在二线ESR1突变治疗中具有差异化优势[17] 临床获益与安全性 - Vepdegestrant的中位无进展生存期（mPFS）为5.0个月，相较于Fulvestrant的2.1个月，显示出显著的疗效改善[33] - 在ESR1突变患者中，Vepdegestrant的临床获益率（CBR）为42.1%，而Fulvestrant为20.2%，优势比为2.88（95% CI: 1.57–5.39），P<0.001[39] - Vepdegestrant的客观反应率（ORR）为34.3%，Fulvestrant为28.7%，优势比为1.29（95% CI: 0.89–1.91），P=0.16[39] - Vepdegestrant在整体患者中的事件发生率为59%，Fulvestrant为64%，中位随访时间分别为7.4个月和7.2个月[35] - Vepdegestrant的治疗相关不良事件（TRAEs）发生率为57%，而Fulvestrant为40%[45] - Vepdegestrant的任何级别不良事件发生率为87%，Fulvestrant为81%[45] - Vepdegestrant的3级及以上不良事件发生率为23%，Fulvestrant为18%[45] - Vepdegestrant在ESR1突变患者中显示出一致的PFS获益，HR为0.57（95% CI: 0.42–0.77）[44] - Vepdegestrant在2L+ ESR1突变患者中显示出显著的临床益处，可能成为最佳治疗选择[60] 未来展望 - Arvinas和Pfizer计划在未来几周向美国食品药品监督管理局提交新药申请（NDA）[60]

Arvinas (ARVN) Update / Briefing June 02, 2025 08:00 AM ET Speaker0 Ladies and gentlemen, thank you for standing by. My name is Desiree, and I will be your conference operator today. At this time, I would like to welcome everyone to the Arvinas ASCO Data Conference Call. All lines have been placed on mute to prevent any background noise. After the speakers' remarks, there will be a question and answer session. I would now like to turn the conference over to Jeff Boyle, Investor Relations. You may begin. Spe ...

Pivotal Phase 3 VERITAC-2 clinical trial results presented at ASCO demonstrate 2.9-month improvement in median progression-free survival when compared to fulvestrant in second line-plus patients with an estrogen receptor 1 mutationVepdegestrant was generally well tolerated, with few discontinuations and low rates of gastrointestinal-related adverse events Vepdegestrant is the first and only PROteolysis TArgeting Chimera (PROTAC) evaluated in a Phase 3 clinical trial and the first to show benefit in patients ...

Arvinas, Inc. (ARVN) closed the last trading session at $7.50, gaining 3.7% over the past four weeks, but there could be plenty of upside left in the stock if short-term price targets set by Wall Street analysts are any guide. The mean price target of $14.62 indicates a 94.9% upside potential.The mean estimate comprises 17 short-term price targets with a standard deviation of $5.19. While the lowest estimate of $8 indicates a 6.7% increase from the current price level, the most optimistic analyst expects th ...

NEW HAVEN, Conn., May 30, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company working to develop a new class of drugs based on targeted protein degradation, today announced that management will participate in a fireside chat at the Jefferies Global Healthcare Conference on Thursday, June 5 at 2:35 p.m. ET in New York City. A live audio webcast of the presentation will be available here and under “Events and Presentations” on the Investors and Media section of the Co ...