SHANGHAI, Jan. 20, 2025 /PRNewswire/ -- CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces that KJ-C2320, an allogeneic CAR T-cell therapy targeting CD38, has administered the first dose to a patient in an investigator-initiated trial (IIT).KJ-C2320 is developed based on CARsgen's THANK-uCAR® platform. An investigator-initiated trial is ongoing in China to evaluate KJ-C232 ...

SHANGHAI, Jan. 13, 2025 /PRNewswire/ -- CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces that KJ-C2219, an allogeneic CAR T-cell therapy targeting CD19/CD20, has administered the first dose to a patient in an investigator-initiated trial (IIT).KJ-C2219 is developed based on CARsgen's THANK-u Plus platform and is designed for the treatment of hematologic malignancies and ...

SHANGHAI, Dec. 30, 2024 /PRNewswire/ -- CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces the positive results from the pivotal Phase II clinical trial CT041-ST-01(NCT04581473). This study is an open-label, multicenter clinical trial evaluating the safety and efficacy of satricabtagene autoleucel ("satri-cel", CT041) (an autologous CAR T-cell product candidate against Cla ...

Avis Budget Group, Inc. (CAR) is benefiting from strong car rental demand, strategic fleet management, technology investments, and share buybacks, boosting profitability and investor confidence. The Zacks Consensus Estimate for the company’s 2025 earnings is 1.38 per share, indicating an 182% year-over-year increase.The car rental industry, particularly in North America, has been experiencing strong demand driven by changes in consumer behavior, including an emphasis on short-term vehicle access rather than ...

Autolus Therapeutics plc (NASDAQ: AUTL ) is a promising CAR T-cell biotech that recently received FDA approval for AUCATZYL. This is AUTL's main value driver, and it's indicated for relapsed or refractory B-cell precursor acute lymphoblastic leukemia [ALL]. Based onMy name is Myriam Hernandez Alvarez. I received the Electronics and Telecommunication Engineering degree from the Escuela Politecnica Nacional, Quito, Ecuador, the M.Sc. degree in computer science from Ohio University, Athens, OH, USA, a graduate ...

– Mercedes-Benz's elegant midsize luxury car has outdone its competitors to secure MotorTrend's Golden Calipers for the second time in five years –LOS ANGELES, Nov. 20, 2024 /PRNewswire/ -- MotorTrend Group, a Warner Bros. Discovery company, announced today the Mercedes-Benz E-Class as its 2025 Car of the Year award winner. The new E-Class, available as both a sedan and wagon-crossover, claimed the top spot amongst competitors for its elegant, refreshed design, excellent performance, and technology. MOT ...

Over the weekend, Bristol Myers Squibb & Co BMY shared preliminary data from a Phase 1 study of CC-97540 (BMS-986353), a CD19-directed CAR T Cell Therapy Manufactured Using a Next-generation Process for severe, refractory autoimmune diseases.Data were presented at the American College of Rheumatology 2024.Also Read: Bristol-Myers Faces Renewed $6.7 Billion Lawsuit Over Drug Approval Delays Amid Resolved Trustee IssueCC-97540 (BMS-986353) is an investigational CD19-targeted CAR T cell therapy that expresses ...

公司临床试验进展 - 已对正在进行的复发性卵巢癌CAR - T疗法1期临床试验的第三组中的第一名患者进行给药剂量为100万CAR阳性细胞 是第一组剂量的10倍 [1] - 在前两组患者中未观察到剂量限制性毒性 第二组患者接受的CAR - T细胞剂量是第一组的三倍 在评估剂量限制性毒性的一个月等待期后 开始对第三组第一名患者进行给药 [2] 公司技术及试验相关情况 - 公司的FSHR介导的CAR - T技术靶向卵泡刺激素受体 该受体仅在卵巢细胞 肿瘤血管和某些癌细胞上表达 试验招募至少接受过两种先前疗法的复发性卵巢癌成年女性 旨在评估安全性 确定最大耐受剂量并监测疗效 [3] - 研究的主要研究者表示 由于在前两组患者中未观察到剂量限制安全性问题 已进入下一组评估更高剂量 希望证明CAR - T的耐受性 并对在实体瘤中看到疗效持乐观态度 还提到第一组中的一名患者在输注后一年多有相对稳定甚至轻微改善的情况 基于此提交了试验方案修正案以允许可能受益于额外剂量的患者 预计更高的细胞剂量会提高疗效 第二次剂量可能会进一步提高反应率和持久性 [4] 公司概况 - 公司是一家临床阶段的生物技术公司 专注于癌症的治疗和预防 其治疗组合包括与莫菲特癌症中心合作开发的卵巢癌免疫疗法项目 使用一种新型CAR - T技术 其疫苗组合包括与克利夫兰诊所合作开发的用于治疗和预防乳腺癌和卵巢癌的疫苗以及针对其他难治性癌症的疫苗 公司独特的商业模式是与世界著名研究机构在所有开发阶段合作 [5]

患者治疗情况 - 27岁非裔美国 - 亚洲女性患者患狼疮性肾炎超10年接受无氟达拉滨预处理和单剂量FT819治疗后达到临床缓解且无免疫抑制治疗 [1] - 患者初始病情严重治疗后无≥3级不良事件无CRS ICANS或GvHD且疲劳完全消除 [2] - 无氟达拉滨预处理和单剂量FT819治疗后外周CD19 + B细胞迅速消除B细胞恢复以幼稚型为主 [3] FT819研究情况 - FT819一期自身免疫研究评估安全性药代动力学和抗B细胞活性前三位患者无剂量限制毒性 [5] - 公司正在招募FT819一期自身免疫研究的第二治疗组 [6] 公司技术平台情况 - 公司iPSC产品平台结合多重工程和单细胞选择制造细胞产品克服细胞疗法制造局限 [7] 公司概况 - 公司是临床阶段生物制药公司致力于为患者带来iPSC衍生细胞免疫疗法 [8]

Emerging leadership in allogeneic CAR-T for hematologic malignancies demonstrated by recent P-BCMA-ALLO1 Phase 1 data and new preclinical findings for P-CD19CD20-ALLO1 and P-CD70-ALLO1 Latest preclinical data on P-BCMACD19-ALLO1 demonstrates its potential as a next-generation allogeneic TSCM-rich CAR-T for both autoimmune diseases and oncologyAdvancing innovative strategies to overcome the unique challenges of applying CAR-T to solid tumorsVirtual R&D Day featuring partner Astellas Pharma and Poseida's lead ...