Exhibit 99.1 Dyne Therapeutics Reports Third Quarter 2025 Financial Results and Recent Business Highlights - Topline data from Registrational Expansion Cohort of DELIVER trial of zeleciment rostudirsen (z-rostudirsen, also known as DYNE-251) in DMD on track for December 2025 to support potential submission for U.S. Accelerated Approval in Q2 2026 - - FDA recently granted Breakthrough Therapy Designation to z-rostudirsen for the treatment of patients with DMD amenable to exon 51 skipping - - U.S. sites activ ...

- Topline data from Registrational Expansion Cohort of DELIVER trial of zeleciment rostudirsen (z-rostudirsen, also known as DYNE-251) in DMD on track for December 2025 to support potential submission for U.S. Accelerated Approval in Q2 2026 - - FDA recently granted Breakthrough Therapy Designation to z-rostudirsen for the treatment of patients with DMD amenable to exon 51 skipping - - U.S. sites activated in ACHIEVE trial of zeleciment basivarsen (z-basivarsen, also known as DYNE-101) in DM1; completion o ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ________________ to ________________ Commission File Number: 001-39509 Dyne Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 36-48839 ...

We recently published 10 Big Names Crushing Wall Street. Dyne Therapeutics, Inc. (NASDAQ:DYN) is one of the top-performing stocks on Monday. Dyne Therapeutics soared by 41.18 percent on Monday to close at $24.17 apiece following a comment from investment firm Jefferies that it would likewise benefit from Novartis’ $12 billion planned acquisition of its peer, Avidity Biosciences. In a statement over the weekend, Novartis announced that it would acquire shares of Avidity at a price of $72 apiece, represent ...

Dyne Therapeutics' stock sees record rally, but one analyst says it could still climb a lot further, after a rival got bought out for a big premium. ...

交易核心信息 - 诺华公司以约120亿美元的全现金交易收购Avidity Biosciences [1][6] - 收购价格为每股72美元 较Avidity上周五收盘价有46.5%的溢价 [2] - 交易预计在明年上半年完成 [4] 市场反应与影响 - Avidity Biosciences股价在周一盘中飙升超过40% [2][6] - 同样开发神经肌肉疾病RNA疗法的Dyne Therapeutics股价也飙升超过40% [5][6] - Avidity股价自年初以来已上涨140% Dyne股价也重回正值区间 [5] 战略意义与协同效应 - 收购使诺华获得Avidity的三个针对严重遗传性神经肌肉疾病的后期实验性疗法 [3] - 诺华借此扩大其在RNA疗法领域的布局 获得名为抗体寡核苷酸偶联物（AOC）的RNA治疗平台 [3][4] - 公司预计此次收购将使其2024年至2029年的销售复合年增长率从5%提升至6% [4] 交易相关安排 - 在交易完成前 Avidity将把其早期精准心脏病学项目分拆至一家新公司 [2]

盘前交易概况 - 美国东部时间周一上午8点45分，多只股票在盘前交易中出现显著波动，早期价格变动预示着开盘前的潜在机会 [1] - 盘前交易为活跃交易者提供了识别潜在突破、反转或剧烈价格波动的先机，这些早期动向通常预示着动能可能延续至常规交易时段 [1] 盘前涨幅居前股票 - Click Holdings Limited (CLIK) 涨幅最大，达81%，股价为11.17美元 [3] - Avidity Biosciences, Inc. (RNA) 上涨43%，股价为70.72美元 [3] - Dyne Therapeutics, Inc. (DYN) 上涨37%，股价为23.58美元 [3] - Zenas BioPharma, Inc. (ZBIO) 上涨21%，股价为29.00美元 [3] - ProPetro Holding Corp. (PUMP) 上涨18%，股价为7.47美元 [3] - 生物科技与医药行业公司表现突出，在涨幅前十的股票中占据多数席位 [3] 盘前跌幅居前股票 - Smart Logistics Global Limited (SLGB) 跌幅最大，达37%，股价为3.21美元 [4] - MaxsMaking Inc. (MAMK) 下跌22%，股价为4.08美元 [4] - Prenetics Global Limited (PRE) 下跌14%，股价为14.40美元 [4] - United States Antimony Corporation (UAMY) 下跌14%，股价为10.22美元 [4] - NeurAxis, Inc. (NRXS) 下跌12%，股价为3.01美元 [4] - 物流、金属及 therapeutics 行业部分公司出现显著下跌 [4]

文章来源与作者服务 - 文章作者Terry Chrisomalis运营名为Biotech Analysis Central的医药服务，提供对多家医药公司的深度分析 [1] - 该服务在Seeking Alpha平台的订阅价格为每月49美元，年度计划可享受33.50%的折扣，价格为每年399美元 [1] - 作者所在的投资小组Biotech Analysis Central拥有超过600篇生物技术投资文章库，以及一个包含10多只中小盘股票的投资组合模型 [2]

文章来源与作者服务 - 文章由Terry Chrisomalis发布，其运营名为Biotech Analysis Central的Seeking Alpha市场医药服务 [1] - 该服务提供对多家制药公司的深度分析，月度订阅费为49美元，年度订阅计划可享受33.50%的折扣，价格为每年399美元 [1] - 作者是投资团体Biotech Analysis Central的创建者，拥有一个包含600多篇生物技术投资文章的资料库 [2] 关于Dyne Therapeutics - 作者此前曾撰写关于Dyne Therapeutics的文章，标题为"Dyne: Accelerated Approval Of DYNE-101 Might Be Possible With Surrogate Biomarker" [2]

- Robust improvement demonstrated across diverse set of clinical measures - - Patient-reported outcomes support clinical meaningfulness of improvements in function and strength - - Meaningful improvements in overall disease burden reported by both patients and physicians - WALTHAM, Mass., Oct. 06, 2025 (GLOBE NEWSWIRE) -- Dyne Therapeutics, Inc. (Nasdaq: DYN), a clinical-stage company focused on delivering functional improvement for people living with genetically driven neuromuscular diseases, today annou ...