临床试验进展 - 公司正在按计划在年底前展示RUBY试验和EdiTHAL试验的更多临床数据[4] - 公司完成了RUBY试验青少年队列的入组,并正在为初始青少年队列患者制造药品[4] - 公司完成了EdiTHAL试验成人队列的入组,并继续给患者进行给药[5] - 公司正在按计划在年底前为一个未披露适应症建立体内前期临床验证性证据[6] 财务状况 - 公司拥有充足的现金储备,预计可以维持到2026年[7] - 第二季度净亏损为6760万美元,每股亏损0.82美元[8] - 第二季度合作及其他研发收入下降至50万美元,主要由于与合作伙伴的药品供应活动减少[9] - 第二季度研发费用增加至5420万美元,主要与reni-cel项目加速推进以及体内研究和发现相关成本增加有关[10] - 第二季度一般及行政费用增加至1820万美元,主要由于知识产权和专利相关费用增加[11]

On track to present additional clinical data from the RUBY trial and the EdiTHAL trial by year-end In vivo preclinical proof-of-concept for an undisclosed indication on-track by year-end Strong financial position with runway into 2026 CAMBRIDGE, Mass., Aug. 07, 2024 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (Nasdaq: EDIT), a clinical-stage gene editing company, today reported financial results for the second quarter 2024 and provided business updates. "We made significant progress in all three pillars of ou ...

This data readout follows the December 2023 press release, when the company last reported positive safety and efficacy data in 17 patients treated with reni-cel in the RUBY and EdiTHAL studies (11 and six patients, respectively). Editas stated that it has now dosed more than 20 SCD patients, completed adult cohort enrollment, and opened and enrolled patients in the adolescent cohort in the Ruby study, implicating significant progress. All patients in both studies demonstrated successful neutrophil and plate ...

EHA RUBY oral presentation on Saturday, June 15 at 11:30 a.m. CEST/5:30 a.m. EDT "I am encouraged by these results from the RUBY trial, demonstrating this investigational gene editing medicine has been well-tolerated and shows promising efficacy for people living with sickle cell disease. Treatment with reni-cel showed a favorable safety profile and promising preliminary efficacy, supporting further investigation as a differentiated gene-edited medicine for patients with SCD. We look forward to continuing t ...

All patients treated in the EdiTHAL trial maintained hemoglobin levels above the transfusion threshold and are transfusion-free post-renizgamglogene autogedtemcel (reni-cel) infusion In the EdiTHAL trial to date, reni-cel was well-tolerated and continues to demonstrate a safety profile consistent with myeloablative conditioning with busulfan and autologous hematopoietic stem cell transplant by all patients (N=7). Following treatment with reni-cel, all EdiTHAL patients had early and robust increase of total ...

Editas Medicine, Inc. (NASDAQ:EDIT) RBC Capital Markets Global Healthcare Conference Call May 15, 2024 2:05 PM ET Company Participants Gilmore O'Neill - Chief Executive Officer Conference Call Participants Luca Issi - RBC Capital Markets Luca Issi Thanks, everybody. Luca Issi, senior biotech analyst here at RBC Capital Markets. Today is our great privilege to have Editas for us with us with a fireside chat. Representing the company, we have Gilmore O'Neill, Chief Executive Officer. Gilmore thanks so much fo ...

业绩总结 - Editas Medicine 公司在过去几个月取得了实质性进展[4] - Reni-cel 资产已进入关键阶段，FDA同意将其从1/2期转为1/2/3期[4] - 在RUBY研究中，患者胎儿血红蛋白上调幅度超过40%，所有患者贫血得到纠正[8] - Reni-cel BLA申请的时间表尚未确定，但可能在明年下半年提交[12] 新产品和新技术研发 - Editas 公司正积极推进in vivo编辑的前临床概念验证[6] 市场扩张和并购 - 公司专注于监控并关注市场上新型治疗药物的发展，特别是针对移植领域的治疗药物[25] - 公司对中东地区以及美国以外市场的镰状细胞病治疗机会持乐观态度，认为中东地区市场潜力巨大[26] - 公司在寻找合作伙伴方面更加关注中东地区的血红蛋白病患者数量多、移植基础设施完善的机会[27] 其他新策略和有价值的信息 - 公司在研究中着重关注功能性上调，而非其他公司更多关注下调的策略[29] - 公司的交易可以在药物生命周期的任何阶段发生，交易结构灵活，根据合作伙伴的需求进行调整[31]

CAMBRIDGE, Mass., May 14, 2024 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (NASDAQ:EDIT), a clinical-stage gene editing company, today announced that two abstracts, including one oral presentation and one poster presentation, detailing clinical data from the RUBY and EdiTHAL trials of renizgamglogene autogedtemcel (reni-cel) have been accepted for presentation at the European Hematology Association (EHA) Hybrid Congress being held June 13-16, 2024, in Madrid, Spain, and via livestream. Clinical data from pati ...

Research includes the first-ever application of AsCas12a in vivo, optimized LNP delivery, and gene editing RNA guide modifications Data to support development of the Company's in vivo gene editing medicines pipeline   CAMBRIDGE, Mass., May 10, 2024 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (NASDAQ:EDIT), a clinical-stage gene editing company, today announced the presentation of preclinical data demonstrating several in vivo capabilities towards developing transformative in vivo gene editing medicines. The C ...

Editas Medicine, Inc. (EDIT) incurred a loss of 76 cents per share in the first quarter of 2024, wider than the Zacks Consensus Estimate of a loss of 63 cents. The company had reported a loss of 71 cents per share in the year-ago quarter.Collaboration and other research and development (R&D) revenues, which comprise the company’s top line, were $1.1 million in the first quarter, down from $9.8 million reported in the year-ago quarter. The reported figure missed the Zacks Consensus Estimate of $12 million. T ...