Terns Pharmaceuticals Inc. (NASDAQ:TERN) stock is trading higher on Monday, with a session volume of 24.36 million, compared to its average volume of 1.31 million, according to Benzinga Pro.The company announced that data from the ongoing CARDINAL trial of TERN-701 in participants with previously treated chronic myeloid leukemia (CML) will be presented at the 67th American Society of Hematology Annual Meeting and Exposition.The ASH abstract reports data from the ongoing dose-escalation and dose-expansion ph ...

Unprecedented Phase 1 CML efficacy data with 64% MMR achievement by 24 weeks in a refractory patient population Encouraging safety and tolerability profile at all doses evaluated Company to host investor update call on December 8th at 4:30pm ET FOSTER CITY, Calif., Nov. 03, 2025 (GLOBE NEWSWIRE) -- Terns Pharmaceuticals, Inc. (Terns or the Company) (Nasdaq: TERN), a clinical stage oncology company, today announced that data from the ongoing CARDINAL trial of TERN-701, a novel investigational allosteric BCR: ...

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文章核心观点 - Terns Pharmaceuticals公司宣布其口服GLP-1受体激动剂TERN-601的二期临床试验顶线结果，并决定终止该项目的开发，公司将重新聚焦于肿瘤学领域[2][6] 关键试验结果 - 在超过500毫克剂量组中，观察到最大安慰剂调整体重减轻为4.6%，显示出统计学显著的体重减轻[3] - 不同剂量组的安慰剂调整体重减轻数据分别为：250毫克组-1.8%，500毫克慢速递增组-3.6%，500毫克组-4.6%，750毫克组-3.0%[3] - 500毫克和750毫克剂量的p值低于0.01，具有统计学显著性[3] 安全性概况 - 12%的参与者因不良事件停止治疗，主要为胃肠道问题[4] - 胃肠道不良事件通常为轻度或中度，包括恶心（56%）、呕吐（26.9%）、便秘（11.9%）和腹泻（9.7%），与剂量相关但未发生严重情况[4] - 三名参与者在治疗后出现3级肝酶升高，其中两例可能与药物相关并与药物性肝损伤一致[4] 公司战略调整 - 基于试验结果未达到差异化口服GLP-1RA治疗的高标准，公司决定终止TERN-601项目[6] - 公司将不再在代谢疾病领域进行进一步投资，重新聚焦于肿瘤学项目TERN-701[6] - TERN-701是一种用于治疗慢性髓性白血病的全osteric BCR-ABL抑制剂，其CARDINAL一期试验数据预计在本季度公布[6]

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On Tuesday, Terns Pharmaceuticals Inc. (NASDAQ:TERN) shared topline 12-week results from its FALCON Phase 2 trial of TERN-601.TERN stock is struggling to find support. Check the fundamentals hereThe therapy is an oral GLP-1 receptor agonist (GLP-1RA) as a potential treatment for obesity in adults without diabetes.Also Read: Eli Lilly’s Rare Weight Loss Data Miss Could Benefit CompetitorsWeight LossAt a 250 mg dose, placebo-adjusted weight loss was 1.8%, which was not statistically significant with p=0.056.A ...

Terns Pharmaceuticals said on Tuesday it will stop developing its experimental obesity drug after a mid-stage trial showed modest weight loss and raised safety concerns. ...

Results show maximum placebo-adjusted weight loss of 4.6% with 12% treatment discontinuation due to adverse events Asymptomatic, reversible grade 3 liver enzyme elevations occurred in three participants during post-treatment follow-up period, two of which were deemed drug related Company will not advance TERN-601 or invest in other metabolic assets Reiterates focus on TERN-701, a potential best-in-class allosteric BCR-ABL inhibitor, for chronic myeloid leukemia with clinical data this quarter FOSTER CITY, C ...

公司管线进展 - Terns Pharmaceuticals开发TERN-501用于代谢功能障碍相关脂肪性肝炎及GLP-1药物联合疗法[1] - TERN-701作为潜在癌症疗法处于1期研究阶段 预计第四季度公布数据[1] - Terns Pharmaceuticals近期启动TERN-601为期12周的2期减重临床试验 预计第四季度数据读出[3] 口服GLP-1竞争格局 - 口服药物生产成本低于皮下注射剂型[3] - 口服药物制造商有机会扩大生产并覆盖更多患者群体[2] - 基于生物技术公司口服GLP-1药物最新进展 Terns Pharmaceuticals面临激烈市场竞争[2] 肥胖治疗市场前景 - 抗肥胖领域仍处于发展初期 预计至少到2030年前保持快速增长[5] - 该领域将成为制药行业收入最大的治疗领域[5] - 成功药企将获得巨大财务收益并可能产生超越市场的回报[5] Rhythm Pharmaceuticals业务聚焦 - 公司专注于罕见病导致的肥胖治疗市场[7] - Imcivree于2020年获批用于特定蛋白质缺乏症患者体重管理[7] - 第二季度收入增长66.8%至4850万美元[7] Rhythm临床进展 - setmelanotide在下丘脑损伤所致肥胖患者中取得积极3期结果[8] - 已就该适应症提交监管申请 可能于年底前获得批准[8] - bivamelagon在2期下丘脑性肥胖研究中表现优异 计划明年启动3期试验[9] 目标市场规模 - 在美国、欧洲和日本市场目标患者群体达35,500人[10] - 目前尚无针对下丘脑性肥胖体重管理的获批疗法[10] - bivamelagon作为口服制剂较setmelanotide皮下注射具有额外优势[9] 投资风险因素 - Terns Pharmaceuticals股价表现高度依赖TERN-601中期研究进展[6] - 若试验失败可能导致股价大幅下跌[6] - Rhythm Pharmaceuticals面临临床或监管挫折风险[11]

会议介绍 - 摩根士丹利医疗健康团队Kelly McCarthy主持Terns Pharma公司会议 [1] - Terns Pharma首席执行官Amy Burroughs及首席开发官Scott Harris参与会议 [1] - 会议属于摩根士丹利医疗健康大会的组成部分 [1] 参会人员 - 摩根士丹利方代表为医疗健康团队Kelly McCarthy [1] - Terns Pharma方代表包括首席执行官Amy Burroughs和首席开发官Scott Harris [1] 会议声明 - 需查阅摩根士丹利研究披露网站www.morganstanley.com/researchdisclosures获取重要披露信息 [2] - 相关问题需联系摩根士丹利销售代表 [2]