Aryna Sabalenka becomes first woman to defend US Open title in more than a decadeAI-powered Aryna Sabalenka ad goes viral with 233M Instagram views and Times Square billboard during US OpenIM8 achieves 300,000+ customer purchases and 6 million servings in just 9 months since launch CHARLOTTE, N.C., Sept. 08, 2025 (GLOBE NEWSWIRE) -- Prenetics Global Limited (NASDAQ: PRE), a leading health sciences company, and its premium supplement brand IM8, co-founded by David Beckham, today extends heartfelt congratulat ...

核心观点 - 新型双特异性抗体pumitamig联合化疗在广泛期小细胞肺癌一线治疗中显示出76.3%的客观缓解率和100%的疾病控制率 中位无进展生存期达68个月 安全性可控且无新安全信号[1][2][4] - 该数据支持其可能成为广泛期小细胞肺癌新标准治疗方案 目前全球关键III期试验ROSETTA LUNG-01正在进行中[4][5] 临床试验数据 - 在43名未经治疗的广泛期小细胞肺癌患者中 38名可评估疗效患者确认客观缓解率达76.3% 其中20mg/kg剂量组达85.0% 30mg/kg剂量组达66.7%[2] - 疾病控制率为100% 肿瘤大小平均最佳百分比变化显示肿瘤缩小56.7% 895%患者实现早期肿瘤缩小[2] - 中位无进展生存期为68个月 20mg/kg剂量组63个月 30mg/kg剂量组70个月 中位总生存期数据尚未成熟[2] - 安全性方面 3级及以上治疗相关不良事件在剂量水平1有1例患者 剂量水平2有5例患者 停药率为14%[2] 疾病背景与医疗需求 - 小细胞肺癌占所有肺癌病例15% 全球每年新增约25万例 是最具侵袭性的肺癌类型[8] - 晚期广泛期小细胞肺癌5年相对生存率仅为5% 尽管60-70%患者对当前标准治疗初始有反应 但多数在数月内进展[2][8] - 当前标准一线治疗为铂类化疗联合依托泊苷 尽管加入免疫检查点抑制剂改善了生存结果 但仍需新的治疗方案[8] 药物机制与开发进展 - pumitamig是靶向PD-L1和VEGF-A的双特异性抗体 通过PD-L1检查点抑制恢复T细胞能力 同时中和VEGF-A阻断肿瘤血管生成[9] - 作用机制可能通过靶向肿瘤细胞PD-L1定位抗VEGF活性至肿瘤微环境 提高治疗精确度并减少全身暴露[9] - 目前已治疗超过1200名患者 超过20项临床试验正在进行或计划中 涉及10多种实体瘤适应症[10] - 2025年获得美国FDA孤儿药资格认定 用于小细胞肺癌治疗[5] 合作开发与后续计划 - pumitamig由BioNTech与百时美施贵宝联合开发 是全球首个在晚期小细胞肺癌全球人群中报告的PD-L1 x VEGF双特异性抗体数据[3][4] - 全球关键III期试验ROSETTA-LUNG-01正在招募患者 比较pumitamig联合化疗与atezolizumab联合化疗一线治疗未经治疗广泛期小细胞肺癌[5] - 另有两项全球注册潜力试验正在推进 分别针对一线非小细胞肺癌和一线三阴性乳腺癌[10]

LOS ANGELES and SHENZHEN, China, Sept. 08, 2025 (GLOBE NEWSWIRE) -- MILESEEY TOOLS, a sub-brand of MILESEEY Group, today announced its official partnership with the American Institute of Architects (AIA) as a Cornerstone Partner. This alliance marks a significant step in MILESEEY’s global strategy and underscores its long-term commitment to precision, efficiency, and sustainable innovation. The AIA, established in 1857, is the leading professional association for architects in the United States, representin ...

TORONTO, Sept. 08, 2025 (GLOBE NEWSWIRE) -- Urbana Corporation ("Urbana") (TSX and CSE: URB, URB.A) is pleased to announce that it has made an additional investment of $3.5 million in Tetra Digital Group Inc. (“Tetra”), Canada’s leading institutional digital technology and financial services provider, by participating in Tetra’s recent round of equity financing, which closed on September 4, 2025 (the “New Financing”). Urbana holds a majority equity interest in Tetra. Tetra raised a total of $10M in this New ...

Singapore , Sept. 08, 2025 (GLOBE NEWSWIRE) -- YY Group Holding Limited (Nasdaq: YYGH) (“YY Group” or the “Company”), a Singapore-headquartered provider of integrated facility management and on-demand staffing solutions, today announced preliminary and unaudited financial results for the first half ended June 30, 2025. The Company expects to report revenue of $29.4 million, representing a 53 percent year-over-year increase. Gross profit of $4.6 million is anticipated to increase by nearly 100% from the prio ...

GUANGZHOU, CHINA, Sept. 08, 2025 (GLOBE NEWSWIRE) -- Youxin Technology Ltd (NASDAQ: YAAS) (the “Company”), a software as a service (“SaaS”) and platform as a service (“PaaS”) provider committed to helping retail enterprises digitally transform their businesses, today announced the closing of its previously announced firm commitment underwritten public offering. Gross proceeds to the Company were approximately $6.0 million, before deducting underwriting fees and other offering expenses payable by the Company ...

(2025-09-08) Kitron ASA has completed share buyback in connection with remuneration to the board members. Reference is made to the stock exchange release by Kitron ASA ("Kitron" or the "Company") published on 8 September 2025 regarding initiation of a share buyback program. The Company has completed its share buyback program. Norne Securities AS has been engaged to carry out the buybacks on behalf of the Company pursuant to the EU Market Abuse Regulation article 5. The Company has acquired a total of 14 017 ...

Not for distribution to United States newswire services or for dissemination in the United States. This news release does not constitute an offer to sell or a solicitation of an offer to buy any of the securities in the United States. TORONTO, Sept. 08, 2025 (GLOBE NEWSWIRE) -- Automotive Finco Corp. (NEX: AFCC-H) (the “Company”) is pleased to announce a cash dividend of $0.0513 per common share ($0.205 per common share on an annual basis) to be paid on October 31, 2025 to shareholders of record as of Septe ...

Unaudited consolidated sales revenue of ŽEMAITIJOS PIENAS AB for the first six months of 2025 amounts to EUR 163,7 million, in comparison with the 1st half of 2024 the sales revenue increased by 10,92 %. Net profit (as without audit) of ŽEMAITIJOS PIENAS, AB group for 6 month period of the year 2025, makes 5,4 % of the turnover. The person authorized to provide additional information: Head of LegalArnas Matuzas E-mail: a.matuzas@zpienas.lt ...

On September 20th and 21st, Vita Coco invites New Yorkers to Brooklyn’s Domino Square to enjoy an exclusive outdoor pop-up experience, with workouts led by some of the biggest names in training Vita Coco Unveils the “Concrete Jungle Gym” Experience in Brooklyn On September 20th and 21st, Vita Coco invites New Yorkers to Brooklyn’s Domino Square to enjoy an exclusive outdoor pop-up experience. The Pop-up Features Interactive Challenges and Fitness Classes Designed for High-Intensity Movement The event ...