Montrose Environmental Group (MEG) FY Conference June 04, 2025 05:00 PM ET Speaker0 Alright. I think we're gonna get it kicked off here. It's 04:00. Good afternoon, everyone, and welcome. My name is Tim Mulrooney. I'm the research analyst here that covers Montrose. I'm required to inform you that for a complete list of research disclosures or potential conflicts of interest, please visit our website at WilliamBlair.com. So Montrose is a provider of integrated environmental solutions across three segments, c ...

Hologic (HOLX) FY Conference June 04, 2025 05:00 PM ET Speaker0 Thanks for joining us here as we begin to wrap up the second day of the William Blair Growth Stock Conference. If you haven't met me, I'm Andrew Brackman. I'm the diagnostics analyst here at William Blair that covers Hologic. Today, we're pleased to have the team, including CFO, Carleen Oberton and from Investor Relations, Peter Sattler. I am required to tell you that for a full list of research disclosures, please visit williamblair.com, and t ...

TScan Therapeutics (TCRX) 2025 Conference June 04, 2025 04:55 PM ET Speaker0 My name is Rosenblatt with the Jefferies Investment Banking Team, and it is my pleasure to introduce you to Gavin Macbeth, Chief Executive Officer of T scan Therapeutics. Speaker1 Great. Thank you, and thank you to Jefferies for the opportunity to talk today. So as many of you know, we are a publicly traded company, so I will be making forward looking statements during this talk. So just by way of introduction, T scan is a fully in ...

Corbus Pharmaceuticals Holdings (CRBP) 2025 Conference June 04, 2025 04:55 PM ET Speaker0 I take analyst in Maury Raycroft's team at Jefferies. I'm happy to introduce Yuval Cohen, CEO of Corbus. He's a fireside chat firm, so thank you for joining us today, Yuval. Speaker1 Thank you for having us here. Speaker0 So for those who may be new to the story, can you provide a one minute intro to Corbus? Sure. Speaker1 We are a drug discovery company or a direct development company. We're based just South Of Boston ...

BioCryst Pharmaceuticals (BCRX) 2025 Conference June 04, 2025 04:55 PM ET Speaker0 Hi, everyone. My name is Maury Raycrofton, one of the biotech analysts at Jefferies. With great pleasure, I'd like to welcome Helen Thackery, the Chief R and D Officer from BioChris. Thanks so much for joining us today, Helen. Speaker1 Thanks very much, Maury. Speaker0 And we're going to do a fireside chat discussion. So maybe to start off, for those who are unfamiliar with BioCryst, if you can set the stage and talk about Or ...

Kyverna Therapeutics (KYTX) 2025 Conference June 04, 2025 04:55 PM ET Speaker0 Good afternoon and welcome to Jefferies twenty twenty five Global Healthcare Conference. My name is Ashwin Serpaneini with the Jefferies Investment Banking team and it's my great pleasure to introduce Warner Biddle, CEO of Qiverna Therapeutics. Qiverna is focused on liberating patients through the curative potential of cell therapy. Its lead CAR T cell therapy candidate, KYV-one hundred one, is advancing through late stage clinic ...

Allogene Therapeutics (ALLO) 2025 Conference June 04, 2025 04:55 PM ET Speaker0 We are very pleased to have the CEO of Allogene here with us, Doctor. David Chang. Allogene, despite the volatility of the markets, is obviously continuing to execute on the, I call it phase three, but pivotal phase two randomized study in a consolidation approach to first line DLBCL. And they have been working on that study, but also had some recent announcements on the last earnings. And so maybe it would be a good place to st ...

Arthur J. Gallagher (AJG) Update / Briefing June 04, 2025 04:30 PM ET Speaker0 Good afternoon, and welcome to Arthur J. Gallagher and Company's Quarterly Investor Meeting with Management. Participants have been placed on a listen only mode. Your lines will be open for questions following the presentation. Today's call is being recorded. If you have any objections, you may disconnect at this time. Some of the comments made during this investor meeting, including answers given in response to questions, may co ...

纪要涉及的行业和公司 - 行业：生物科技、医疗健康、细胞治疗 - 公司：Adicet Bio (ACET) 纪要提到的核心观点和论据 公司概况 - 公司是现货型γδ1 CAR T细胞疗法领域的领导者，拥有两条临床管线和两条临床前管线 [3][4] γδ1 T细胞疗法优势 - **自身免疫领域**：现货型，无需白细胞单采和个性化制造；耐受性更好，激活后不分泌大量IL - 6，CRS和ICANS的发生率和严重程度较低，有望在社区环境中使用；能完全清除血液和淋巴结中的CD19阳性B细胞 [4][5][6] - **实体瘤领域**：具有先天和适应性抗肿瘤活性，有助于解决肿瘤异质性问题；能向组织归巢，即使在营养缺乏和低氧环境中也能发挥作用 [7] CD20靶向疗法 - **肿瘤学数据**：在MCL中，CR率与自体细胞疗法相当，完全缓解的中位持续时间为17.5个月；在DLBCL中，CR率与自体细胞疗法如eschartha相同，但持久性较低；ADI - 1的药代动力学与自身免疫患者中CD19自体CAR T相当；γδ1 CAR T在淋巴结中的暴露量比自体CAR T高约5 - 10倍，能完全清除淋巴结中的CD19 B细胞 [9][10][11] - **向自身免疫疾病的转化**：自体CAR T在自身免疫疾病中持续约30 - 90天，之后B细胞开始恢复；ADI - 1在剂量水平3E8和1E9时，持续时间也在30 - 90天，且能完全清除CD19 B细胞，这为自身免疫疾病的治疗提供了参考 [14][15][16] 自身免疫疾病研究 - **选择狼疮的原因**：狼疮领域有强有力的CAR T疗效概念验证，能显著改善疾病评分，使患者达到免疫抑制剂停用或接近缓解的状态 [19] - **扩展适应症标准**：有CD20可能有效的证据；存在巨大未满足的医疗需求；γδ1 T细胞对相关组织有归巢性 [20][21][22] - **研究设计**：起始剂量为3E8，下一个剂量水平为1E9；患者通常经过多线治疗，需要有意义的治疗方法 [23][24] - **初步临床数据**：预计下半年公布的初始数据集将聚焦SLE和LN患者，至少有6名患者，随访时间至少3个月；投资者可关注SLAIT2K评分，其能反映CAR T的跨器官疗效 [28][31][32] 实体瘤研究 - **选择肾细胞癌的原因**：γδ1 T细胞具有组织归巢性、先天和适应性抗肿瘤活性，且可现货给药；使用CD27靶向CD70，需要较低的抗原表达，可能更有效；能攻击表达CD70的活化T细胞，可能导致更高的Cmax和持久性 [37][38][39] - **研究设计和数据预期**：纳入经过PD - 1和VEGF靶向治疗的患者；预计下半年有数据，至少有6名患者，随访时间3个月 [41] - **CD70靶向策略的适用性**：约80%的透明细胞RCC患者肿瘤表达CD70，此外还有近20种癌症部分患者表达CD70，但需要伴随诊断来筛选患者 [44] 临床前项目 - 公司预计今年下半年公布更多数据，过去五年致力于提高γδ1 CAR T细胞的效力，目前这些项目已成熟 [46][47] 公司计划和里程碑 - **2025 - 2026年**：下半年预计公布SLE和LN以及ADI - 270的数据，明年可能有更多患者的临床数据和现有患者的持久性数据；两个临床前项目将推进到IND和临床开发阶段 [48][49] 其他重要但是可能被忽略的内容 - 德国研究是在紧急使用法规下进行的，没有正式的纳入排除标准，主要根据患者病史选择患者；公司SLE患者的纳入标准是至少经过两种不同治疗，包括可能使用的皮质类固醇，且疾病仍在进展 [25] - 细胞疗法在自身免疫疾病中可显著改善SLEDI评分，使疾病得到控制，有望成为新的治疗类别，带来巨大商业机会 [34][35]

WEX (WEX) FY Conference June 04, 2025 04:20 PM ET Speaker0 I'm required to inform you that a complete list of research disclosures or potential conflicts of interest can be found on our website, williamblair.com. So with that, pleasure to introduce Melissa Smith, chairman and CEO of WEX as well as Steve Elder who runs the company's IR. And Melissa will walk us through a presentation. I expect we'll have time for a little bit of Q and A in this room and then there'll be a breakout session after. Speaker1 Tha ...