BD FACSDiscoverâ"¢ A8 Cell Analyzer to Enable Investigation of 30+ Cellular Characteristics to Capture Key Biological Insights and Support Planned 1,000-Person Immune Profiling Study FRANKLIN LAKES, N.J., Dec. 18, 2025 /PRNewswire/ -- BD (Becton, Dickinson and Company) (NYSE: BDX), a leading global medical technology company, today announced a strategic collaboration with the Institute for Immunology and Immune Health (I3H) at the University of Pennsylvania, to advance research in deep human immune profilin ...

RICHMOND, Va.--(BUSINESS WIRE)--CarMax, Inc. (NYSE:KMX) today reported results for the third quarter ended November 30, 2025. Third Quarter Highlights:(1) (1) Comparisons to the prior year's third quarter unless otherwise stated Interim CEO Commentary: "I'm honored to serve as Interim President and CEO at this important juncture for CarMax. Our unmatched physical and digital infrastructure, beloved national brand, and award-winning culture provide us with incredible advantages. Despite these advantages, bas ...

公司成本削减进展 - 大众汽车集团核心品牌负责人表示 公司在成本削减方面取得进展 [1] - 成本削减措施包括裁员和集团层面的节约 [1] 公司运营措施 - 公司正在推进裁员以降低人力成本 [1] - 公司正在集团层面实施节约措施 [1]

By Marc Jones, Global Markets Correspondent ...

By Marc Jones LONDON, Dec 18 (Reuters) - By Marc Jones, Global Markets Correspondent Investors' top focus today is the delayed - and slightly unusual - U.S. consumer price inflation report, which will be an important marker for whether the Federal Reserve is likely to keep cutting interest rates next year. Meanwhile, Wall Street will be watching the tech sector again after the latest signs of bubble trouble due to ​big spending AI plans at the likes of Oracle. I’ll get into all the market news below. ...

Two Harbors Investment ( TWO ) is set to be acquired by UWM Holdings Corporation ( UWMC ) (the publicly traded indirect parent of United Wholesale Mortgage, the #1 overall mortgage lender in America) inI ventured into investing in high school in 2011, mainly in REITs, preferred stocks, and high-yield bonds, starting a fascination with markets and the economy that has not faded despite the years. More recently I have been combining long stock positions with covered calls and cash secured puts. I approach inv ...

核心观点 - 礼来公司宣布其口服GLP-1受体激动剂orforglipron在ATTAIN-MAINTAIN三期临床试验中取得积极顶线结果，达到了主要及所有关键次要终点，证明其在52周内能有效维持先前使用Wegovy或Zepbound减掉的体重 [1] - 礼来已向美国FDA提交了orforglipron用于治疗肥胖症的新药申请 [1][5] 临床试验结果 - **主要终点**：在52周时，与安慰剂相比，orforglipron在维持体重减轻百分比方面具有优效性 [1][2] - **体重维持数据（52周）**： - 从Wegovy转为orforglipron的患者，平均仅反弹0.9公斤 [1][2] - 从Zepbound转为orforglipron的患者，平均反弹5.0公斤 [2] - **体重维持数据（24周）**： - 从Wegovy转为orforglipron的患者，体重较ATTAIN-MAINTAIN基线变化为-0.1公斤，而安慰剂组增加9.4公斤 [2] - 从Zepbound转为orforglipron的患者，体重较基线增加2.6公斤，而安慰剂组增加9.1公斤 [2] - **具体体重数据**： - Wegovy转orforglipron组：起始体重113.5公斤，转换时体重95.0公斤，52周维持治疗后体重95.9公斤 [3] - Zepbound转orforglipron组：起始体重115.8公斤，转换时体重90.9公斤，52周维持治疗后体重95.9公斤 [3] 药物安全性与试验设计 - **安全性**：orforglipron在ATTAIN-MAINTAIN试验中的安全性和耐受性特征与之前的三期研究一致，最常见不良事件为胃肠道相关，严重程度多为轻至中度 [3] - **停药率**：因不良事件导致的停药率，orforglipron组（来自Wegovy）为4.8%，安慰剂组（来自Wegovy）为7.6%；orforglipron组（来自Zepbound）为7.2%，安慰剂组（来自Zepbound）为6.3% [4] - **试验设计**：ATTAIN-MAINTAIN是一项为期52周、随机、双盲、安慰剂对照的三期试验，共纳入376名参与者，以3:2的比例随机接受orforglipron最大耐受剂量或安慰剂 [6] - **试验入组**：orforglipron的ATTAIN全球三期临床开发项目已在两项全球注册试验中招募了超过4500名肥胖或超重患者 [8] 药物背景与市场定位 - **药物特性**：orforglipron是一种每日一次口服小分子GLP-1受体激动剂，可在一天中任何时间服用，无需限制食物和水摄入 [5] - **研发进展**：礼来正在开展orforglipron用于治疗2型糖尿病和体重管理的三期研究，同时也在研究其用于治疗阻塞性睡眠呼吸暂停、高血压、膝骨关节炎等肥胖相关疾病的潜力 [5] - **监管状态**：orforglipron已获得美国FDA授予的局长国家优先审评券 [5] 相关背景：SURMOUNT-5试验 - **试验目的**：SURMOUNT-5是一项为期72周的3b期试验，旨在比较Zepbound与Wegovy在肥胖或超重成人中的疗效 [9] - **试验结果**：在72周时，Zepbound治疗组平均体重减轻20.2%，而Wegovy治疗组平均体重减轻13.7% [9] - **试验规模**：该试验在美国和波多黎各随机分配了751名参与者 [9]

th ROSEMONT, Ill.--(BUSINESS WIRE)--US Foods Holding Corp. (NYSE: USFD) announced today that Dave Flitman, Chief Executive Officer, and Dirk Locascio, Chief Financial Officer, will participate in a fireside chat at the 28 Annual ICR Conference in Orlando, FL on Monday, January 12, at 4:30 p.m. EST. Media and investors can listen to a live audio webcast by visiting the Investor Relations page of the company's website at https://ir.usfoods.com/investors/events-and-presentations/default.aspx. A replay of the w ...

VIENNA, Va.--(BUSINESS WIRE)--Spire Global, Inc. (NYSE: SPIR) ("Spire†or "the Company†), a leading global provider of satellite data, analytics and intelligence, has been awarded a contract for the Missile Defense Agency Scalable Homeland Innovative Enterprise Layered Defense (SHIELD) indefinite-delivery/indefinite-quantity (IDIQ) contract with a ceiling of $151B. This contract encompasses a broad range of work areas that allows for the rapid delivery of innovative capabilities to the warfighter with incr ...

公司公告核心 - 加拿大镍业公司宣布了其位于安大略省蒂明斯镍矿区的Midlothian和Bannockburn硫化镍项目的首次矿产资源量估算结果 [2] 蒂明斯镍矿区总体资源 - 公司已在蒂明斯地区公布了八个矿区的资源量估算，总计拥有**39.8亿吨**品位为**0.24%**的探明与推定资源，包含**940万吨**镍金属；以及**49.5亿吨**品位为**0.23%**的推测资源，包含**1150万吨**镍金属 [4][5] - 公司CEO表示，这八个资源点总计**39亿吨**品位**0.24%**的探明与推定资源，含**940万吨**镍；以及**49亿吨**品位**0.23%**的推测资源，含**1150万吨**镍 [3] - 作为对比，历史悠久的萨德伯里镍矿区在开采前的估计资源量为**1900万吨**镍金属 [5] Midlothian项目资源详情 - Midlothian项目首次估算的资源全部为推测资源，总量为**5.95亿吨**，镍平均品位为**0.28%**，包含**168万吨**镍金属 [8][12] - 该资源估算仅覆盖了目标地球物理区域的约**45%**，资源体大致长**2.5公里**，宽**520米**，深**500米**，向东和深部保持开放 [7][8] - 该项目还存在一个**4.34亿至9.80亿吨**、镍品位介于**0.25%至0.27%**之间的勘探目标 [8] Bannockburn项目资源详情 - Bannockburn项目首次估算的资源包括：推定资源**6300万吨**，镍品位**0.28%**，含**18万吨**镍金属；推测资源**1.29亿吨**，镍品位**0.27%**，含**34万吨**镍金属 [4][17][21] - 该资源估算覆盖了目标地球物理区域的约**70%**，资源体大致长**1.2公里**，宽**330米**，深**500米**，在各个方向保持开放 [15][17] 项目亮点与比较 - Midlothian项目产出了公司在蒂明斯镍矿区迄今为止**平均品位最高的资源**（0.28% Ni）[3] - 在已公布的八个资源点中，Crawford是最大的资源点，拥有**25.6亿吨**探明与推定资源（品位0.24%）和**16.9亿吨**推测资源（品位0.22%）[6] 下一步计划 - 公司预计将在2026年第一季度公布其第九个资源点Nesbitt的资源量估算 [3] - 在Midlothian，下一步将进行加密钻探，旨在将推测资源升级为推定资源，并继续进行矿物学和冶金学分析以更好了解金属回收率 [23] - 在Bannockburn，勘探钻探将扩展到主矿体附近的橄榄岩体，以显著增加资源量，同时继续进行矿物学和冶金学分析 [26] 技术方法与合规 - 两个项目的资源量估算均由Caracle Creek International Consulting Inc.及其分包商按照CIM（加拿大矿业冶金石油协会）最佳实践指南和定义标准编制 [10][19] - 支持矿产资源量估算的技术报告将在新闻发布后的**45天**内提交至SEDAR+系统 [10][19] - 钻探、取样和分析过程由符合NI 43-101标准的合资格人员监督，并实施了严格的质量保证和质量控制程序 [25][27][28]