临床试验数据亮点 - 在DUPLEX研究中，接受FILSPARI治疗的患者在任何时间点达到尿蛋白肌酐比值低于0.7 g/g的比例显著高于接受厄贝沙坦最大标签剂量治疗的患者，分别为37.5%和21.4%，相对风险为1.8 [3] - 在第108周时，FILSPARI组达到UPCR低于0.7 g/g的患者比例为19%，而厄贝沙坦组为11.2%，相对风险为1.7 [3] - 无论接受何种治疗，达到UPCR低于0.7 g/g阈值的患者发生肾衰竭的风险均较低，分别为3.6%和11.2%，相对风险为0.52 [3] 长期疗效与风险关联 - 在DUPLEX对齐的RaDaR队列中，在24个月时达到UPCR低于0.7 g/g与随后60个月随访期间肾衰竭风险降低相关，风险比为0.14 [4] - 在24个月内任何时间点达到UPCR低于0.7 g/g也观察到类似的风险降低，风险比为0.27 [4] - 基于DUPLEX研究中蛋白尿的相对减少，预测FILSPARI治疗患者在五年内肾衰竭事件风险显著降低24%，风险比为0.76 [8] 疾病背景与市场潜力 - 局灶节段性肾小球硬化症是一种罕见的蛋白尿性肾脏疾病，在美国估计影响超过40,000名患者，欧洲的患病率相似 [7] - 该疾病以进行性肾脏瘢痕化为特征，常导致肾衰竭，目前尚无FDA批准的FSGS药物治疗方案 [7] - DUPLEX研究是迄今为止FSGS领域规模最大的干预性研究，也是唯一一项针对最大剂量活性对照药的研究 [6] 公司近期动态 - 公司管理层将参与2025年11月举行的多个投资者会议，包括古根海姆第二届年度医疗保健创新会议、Stifel 2025医疗保健会议等 [25] - 公司计划于2025年10月30日美国金融市场收盘后报告第三季度财务业绩 [29]

Photo by BeInCrypto 'Tis the season to be jolly and listen to Mariah Carey on repeat. But, amidst this celebration, many Christmas-themed tokens are beginning to take the spotlight. However, not all of them are necessarily the best options for investment. Thus, BeInCrypto has analyzed three such Christmas-themed meme coins that present both opportunity and a cautionary tale. Santacoin (SANTA) SANTA has emerged as one of the best-performing Christmas-themed meme coins in the past 24 hours, rising 30% to ...

MARTINS FERRY, OH / ACCESS Newswire / November 6, 2025 / United Bancorp, Inc. (NASDAQ:UBCP) reported diluted earnings per share of $0.34 and net income of $1,931,000 for the three months ended September 30, 2025. For the first nine months of the current year, UBCP reported diluted earnings per share of $0.99 and net income of $5,717,000. ...

In patients with advanced chronic kidney disease (CKD) and diabetes, treatment with rilparencel resulted in statistically significant and clinically meaningful slowing of CKD progressionBilateral kidney injection with rilparencel resulted in a 4.6 mL/min/1.73m2 (78%) improvement in the annual decline of estimated glomerular filtration rate (eGFR) slope in Group 1 (n=24) patientsNo rilparencel-related serious adverse events were observed; the overall study safety profile was consistent with previously report ...

薪酬方案投票 - 特斯拉股东将于美国东部时间周四下午4点举行会议，就一项可能价值近1万亿美元的CEO薪酬方案进行投票，会议结束后预计公布投票结果，最终结果将在几天后通过美国证券交易委员会文件披露 [1][2] - 该薪酬方案将授予CEO超过4.23亿股额外股份，若公司达成未来十年内的多项目标，其持股比例将增至约25% [2] - 薪酬方案获得批准的条件是特斯拉市值在10年内从当前的1.5万亿美元增至8.5万亿美元，并达成其他目标，包括多销售1200万辆汽车、1000万份自动驾驶订阅、运营100万辆Robotaxi以及销售100万台Tesla Bot [3] 支持与反对意见 - 支持方包括特斯拉董事会主席，其警告若方案被否决CEO可能离开公司，导致公司价值损失，并认为其愿景对公司 navigate 关键转折点至关重要 [4] - 摩根斯坦利Counterpoint Global团队、佛罗里达州管理委员会、嘉信理财及Baron Capital均表示支持，认为方案使管理层与股东利益一致，且CEO的领导是公司成功的关键 [4] - 反对方包括挪威央行投资管理公司，其担忧奖励规模、股权稀释及关键人物风险未缓解，加州公务员退休系统也因方案规模远超其他公司高管且会进一步集中权力于单一股东而计划投反对票 [5] - 代理咨询公司Glass Lewis和Institutional Shareholder Services建议股东反对该薪酬方案 [5] 公司运营与市场表现 - 特斯拉第三季度交付量创纪录地超过49.7万辆，推动季度营收达到280.9亿美元，超出华尔街预期，部分原因是10月联邦电动汽车购买税收抵免到期 [8] - 近期在欧洲市场面临大众和比亚迪的竞争，销售出现下滑，在挪威下降超50%，荷兰下降近48%，西班牙下降30%，瑞典下降88% [8] - 公司股价年内上涨20%，CEO目前财富估值为5002亿美元，成为今年首位身价达到4000亿和5000亿美元的人 [9] - 品牌咨询公司Interbrand上月将特斯拉评为全球第25大品牌，落后于宝马、梅赛德斯和丰田，指出其排名下降源于电动汽车竞争加剧及CEO的政治立场 [8]

While it's possible to use a personal loan to buy a car, it’s likely not your best financing option. An auto loan typically offers lower interest rates, so it could cost you less than a personal loan. But there are some circumstances where a personal loan could make sense — for instance, if you're buying a car that's too old or has too many miles to qualify for a traditional car loan. Here's a closer look at personal loans vs. auto loans so you can choose the best strategy for your next vehicle. How per ...

Shares of Sinclair ( SBGI ) have been a poor performer over the past year, losing about 21% of their value as the broadcaster has faced pressure from ongoing cord-cutting. While deregulatory efforts from the Trump Administration may enable increased M&A, Sinclair found itself onOver fifteen years of experience making contrarian bets based on my macro view and stock-specific turnaround stories to garner outsized returns with a favorable risk/reward profile. If you want me to cover a specific stock or have a ...

Coinbase. Photo by BeInCrypto The Central Bank of Ireland (CBI) has fined Coinbase Europe Limited €21.46 million for major anti-money-laundering (AML) and counter-terrorist-financing (CTF) monitoring failures.  The fine marks the first enforcement action against a crypto company in Ireland and highlights growing regulatory scrutiny on digital asset exchanges. Coinbase Accused of Anti-Money Laundering Failures The CBI found that Coinbase failed to properly monitor over 30 million transactions worth €176 ...

fadfebrian / Shutterstock.com Quick Read JPMorgan Equity Premium Income (JEPI) delivers a 7.17% dividend yield and generated an 11% income yield over the past 12 months using an options writing strategy. Global X SuperDividend US (DIV) holds 50 equally weighted stocks with a 7.67% dividend yield, focusing on energy, real estate, and utilities rather than technology. Amplify CWP Enhanced Dividend Income (DIVO) combines dividend growth stocks with covered calls, generating a 4.86% yield and 13.52% ann ...

About this content About Emily Jarvie Emily began her career as a political journalist for Australian Community Media in Hobart, Tasmania. After she relocated to Toronto, Canada, she reported on business, legal, and scientific developments in the emerging psychedelics sector before joining Proactive in 2022. She brings a strong journalism background with her work featured in newspapers, magazines, and digital publications across Australia, Europe, and North America, including The Examiner, The Advocate, ...