文章核心观点 - 公司的C1q靶向免疫治疗药物ANX005在治疗重症格林-巴利综合征(GBS)的III期临床试验中取得积极成果 [1][2][3] - ANX005能够快速抑制神经炎症,显著改善多个终点指标,使患者恢复更快更完全 [2][3] - 与安慰剂相比,ANX005治疗组有更多患者在26周内恢复到正常/治疗前健康状态 [3] - 对于具有北美和欧洲基线特征的患者,ANX005的治疗效果更加显著 [4][5] - ANX005单次输注总体耐受性良好,安全性与安慰剂相似 [3][6] - 这些结果证实了ANX005作为首个针对性免疫治疗GBS的潜力 [3][6] 根据目录分别总结 GBS-Disability Scale (GBS-DS) - 第8周时,ANX005组患者处于更好健康状态的可能性是安慰剂组的2.41倍 [3] - 第1周时,ANX005组患者处于更好健康状态的可能性是安慰剂组的7.22倍 [3] - 第4周时,ANX005组患者处于更好健康状态的可能性是安慰剂组的2.49倍 [3] - 第26周时,ANX005组有2.5倍更多患者完全恢复到正常/治疗前健康状态 [3] - 第8周时,ANX005组有2倍更多患者改善3分或以上 [3] - 第8周时,ANX005组有2.5倍更多患者能够跑步或更好 [3] 功能指标 - ANX005组患者较安慰剂组提前31天开始行走 [3] - ANX005组患者较安慰剂组提前28天脱离呼吸机 [3] 具有北美和欧洲基线特征的患者 - 第1周时,ANX005组患者肌力改善8.8分 [4][5] - 第8周时,ANX005组患者处于更好健康状态的可能性是安慰剂组的3倍 [5]

文章核心观点 - 医疗行业中有很多优秀的股票,投资者应该关注那些表现优于同行的公司 [1] - Annexon, Inc.(ANNX)是医疗行业中表现较好的公司之一 [1][4] - Avalo Therapeutics, Inc.(AVTX)也是医疗行业中表现较好的公司之一 [4][5] 公司总结 Annexon, Inc.(ANNX) - 隶属于医疗-生物医药和遗传学行业,该行业目前排名第83位 [6] - 今年以来公司股价上涨29.7%,优于医疗行业平均6.4%的涨幅 [4] - 过去90天内,公司全年盈利预测上调39.7%,显示分析师对公司前景看好 [3] Avalo Therapeutics, Inc.(AVTX) - 隶属于医疗-药品行业,该行业目前排名第83位 [7] - 今年以来公司股价上涨20.8% [4] - 过去3个月内,公司当年盈利预测上调94.5%,目前评级为买入 [5] 行业总结 - 医疗-生物医药和遗传学行业今年以来下跌2.4%,Annexon, Inc.表现优于行业 [6] - 医疗-药品行业今年以来下跌5.9%,Avalo Therapeutics, Inc.表现优于行业 [7] - 医疗行业整体表现较好,Annexon, Inc.和Avalo Therapeutics, Inc.有望继续保持良好表现 [8]

文章核心观点 - 公司正在进行一次公开发行,预计总募集资金为1.25亿美元[1][2] - 公司正在开发针对神经炎症性疾病的新型疗法,已取得了一些临床前验证[6] - 公司正在积极推进中晚期临床试验,希望尽快为患者带来新的治疗方案[6] 公司信息 - 公司名称为Annexon,是一家生物制药公司[6] - 公司专注于开发针对经典补体介导的神经炎症性疾病的新型疗法[6] - 公司的治疗候选药物旨在通过阻断上游C1q来阻止经典补体炎症级联反应[6] - 公司已在重症肌无力、亨廷顿病和地理性萎缩等疾病中取得了临床前验证[6] 融资信息 - 公司正在进行1.3亿股的公开发行,发行价格为每股6.25美元[1] - 此外还有700万份预付款认股权证以每股6.249美元的价格发行[1] - 预计总募集资金为1.25亿美元,扣除承销费用和其他发行费用后的净额[2] - 承销商包括摩根大通、富瑞、TD证券、美银美林和富国银行[3] - 发行完成后,承销商还有30天的超额配售选择权[2]

BRISBANE, Calif., June 05, 2024 (GLOBE NEWSWIRE) -- Annexon, Inc. (Nasdaq: ANNX), a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye, today announced the pricing of its previously announced underwritten public offering of 13,001,120 shares of its common stock at a price to the public of $6.25 per share and, in lieu of common stock to certain investors, ...

文章核心观点 - Annexon公司宣布其主要候选药物ANX005在治疗格林-巴利综合征(GBS)的III期临床试验中取得积极的结果 [1][2][3][4][5] - ANX005 30mg/kg剂量组在GBS-DS量表上显示出2.4倍的显著改善,同时在其他多个次要终点也优于安慰剂组 [2][3][4][5] - ANX005 30mg/kg剂量组患者在各项评估指标上较安慰剂组表现出更快的改善,显示该候选药物有望为GBS患者带来重要的临床获益 [5] - ANX005还能够较安慰剂组显著降低神经元损伤生物标志物NfL的水平 [6] - 虽然ANX005 75mg/kg剂量组在多个指标上优于安慰剂,但未能在主要终点GBS-DS上达到统计学显著性 [7][8] 公司相关 - Annexon公司将ANX005作为其三大旗舰开发项目之一,优先推进其在GBS适应症的开发 [14] - ANX005已获得FDA的快速通道和孤儿药资格认定,以及欧盟的孤儿药资格认定 [13] - 公司正在开展一项真实世界证据研究,以评估III期试验人群与国际GBS结局研究人群的可比性,预计2025年上半年获得结果 [11][12] 行业相关 - GBS是一种罕见的神经系统疾病,每年在美国和欧盟造成超过22,000例住院,目前尚无获批治疗方法,标准治疗为静脉注射免疫球蛋白 [9] - 基于ANX005 30mg/kg剂量的有利III期结果,公司认为一周的C1q抑制是GBS患者的最佳治疗窗口 [10]

Shares of Annexon, Inc. (ANNX) have gained 26.6% over the past four weeks to close the last trading session at $5.99, but there could still be a solid upside left in the stock if short-term price targets of Wall Street analysts are any indication. Going by the price targets, the mean estimate of $14 indicates a potential upside of 133.7%.The mean estimate comprises six short-term price targets with a standard deviation of $8.37. While the lowest estimate of $7 indicates a 16.9% increase from the current pri ...

BRISBANE, Calif., June 04, 2024 (GLOBE NEWSWIRE) -- Annexon, Inc. (NASDAQ:ANNX), a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye, today announced that it has commenced an underwritten public offering of $125 million of shares of its common stock. All of the shares are being offered by Annexon. In addition, Annexon expects to grant the underwriters a ...

BRISBANE, Calif., June 04, 2024 (GLOBE NEWSWIRE) -- Annexon, Inc. (Nasdaq: ANNX), a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye, today announced that it has commenced an underwritten public offering of $125 million of shares of its common stock. All of the shares are being offered by Annexon. In addition, Annexon expects to grant the underwriters a ...

Single Infusion of ANX005 30 mg/kg Met Primary Endpoint, Delivering a Highly Statistically Significant and Clinically Meaningful 2.4-fold Improvement in GBS-DS vs. Placebo at Week 8, p=0.0058 ANX005 Demonstrated Early and Sustained Improvements in Key Secondary Endpoints Including Muscle Strength, Nerve Damage and Ventilation ANX005 Displayed Rapid Target Engagement and was Generally Well-Tolerated Across Doses Real-World Evidence (RWE) Comparability Data Expected in First Half 2025 Conference call and web ...

BRISBANE, Calif., June 03, 2024 (GLOBE NEWSWIRE) -- Annexon, Inc. (NASDAQ:ANNX), a clinical-stage biopharmaceutical company developing a new class of complement-based medicines for people living with devastating inflammatory-related diseases, today announced that it will host a conference call and webcast on Tuesday, June 4, 2024, at 8:30 a.m. ET to discuss GBS phase 3 data. Conference Call and Webcast InformationThe live webcast and replay may be accessed by visiting Annexon's website here. The dial-in num ...